| Literature DB >> 2990177 |
Abstract
Bath applied histamine and 8-bromo-cyclic AMP and intracellularly injected cyclic AMP block-long-lasting after-hyperpolarizations and the accommodation of firing in CA1 pyramidal cells recorded in rat hippocampal slices. This action is due to reduction of a calcium-activated potassium conductance (gK(Ca] and leads to potentiation of excitatory signals including epileptiform discharges. The effects are further potentiated and prolonged by a phosphodiesterase inhibitor (Ro 20-1724).Entities:
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Year: 1985 PMID: 2990177 DOI: 10.1007/bf01983148
Source DB: PubMed Journal: Agents Actions ISSN: 0065-4299