Literature DB >> 6728039

Butyl hydroxy toluene antagonizes the gastric toxicity but not the pharmacological activity of acetylsalicylic acid in rats.

A A van Kolfschoten, F Hagelen, J van Noordwijk.   

Abstract

Butyl hydroxy toluene reduced gastric erosion due to acetylsalicylic acid in the rat, but not the antiinflammatory, anti-pyretic and analgesic activity. By itself, BHT exhibited activity only in the test on analgesia.

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Year:  1984        PMID： 6728039     DOI： 10.1007/BF00495956

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  9 in total

1.  Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs.

Authors:  C A WINTER; E A RISLEY; G W NUSS
Journal:  Proc Soc Exp Biol Med       Date:  1962-12

2.  A method for measurement of analgesic activity on inflamed tissue.

Authors:  L O RANDALL; J J SELITTO
Journal:  Arch Int Pharmacodyn Ther       Date:  1957-09-01

3.  Gastric erosions induced by analgesic drug mixtures in the rat.

Authors:  A J Seegers; L P Jager; J Van Noordwijk
Journal:  J Pharm Pharmacol       Date:  1978-02       Impact factor: 3.765

4.  Interaction between aspirin and paracetamol on the production of prostaglandins in the rat gastric mucosa.

Authors:  A A van Kolfschoten; A Dembinska-Kiec; M Basista
Journal:  J Pharm Pharmacol       Date:  1981-07       Impact factor: 3.765

5.  Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa.

Authors:  B J Whittle; G A Higgs; K E Eakins; S Moncada; J R Vane
Journal:  Nature       Date:  1980-03-20       Impact factor: 49.962

6.  Effects of low levels of butylated hydroxytoluene on the prothrombin index of male rats.

Authors:  O Takahashi; K Hiraga
Journal:  Food Cosmet Toxicol       Date:  1978-10

7.  Species differences in the haemorrhagic response to butylated hydroxytoluene.

Authors:  O Takahashi; S Hayashida; K Hiraga
Journal:  Food Cosmet Toxicol       Date:  1980-06

8.  Antioxidants as agents reducing the toxicity of indomethacin.

Authors:  J Krupińska; H Sobański; J Piotrowicz; B Cebo; J Mazur
Journal:  Acta Biol Med Ger       Date:  1980

9.  The influence of paracetamol on the erosive activity of indomethacin in the rat stomach.

Authors:  A A van Kolfschoten; P Zandberg; L P Jager; J van Noordwijk
Journal:  Agents Actions       Date:  1982-04
  9 in total
  1 in total

1.  Free radicals and lipid peroxidation in ethanol- or aspirin-induced gastric mucosal injury.

Authors:  G Pihan; C Regillo; S Szabo
Journal:  Dig Dis Sci       Date:  1987-12       Impact factor: 3.199
  1 in total

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