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Literature DB >> 6726117

Effects of beta interferon on human fibroblasts at different population doubling levels. Proliferation, cell volume, thymidine uptake, and DNA synthesis.

Abstract

Cellular aging had no effect on the ability of beta interferon to increase cell volume and population doubling time in 76-109 cells, a line of human skin fibroblasts. However, DNA synthesis in cells at high population doubling levels (PDL 55-70) was inhibited after 72 h of beta interferon treatment (1,000 U/ml) while no inhibition of DNA synthesis was observed in cells at middle population doubling levels (PDL 30-40).

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Year: 1984 PMID： 6726117 PMCID： PMC2187310 DOI： 10.1084/jem.159.6.1741

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

33 in total

1. Regulation of chromosome 21-directed anti-viral gene(s) as a consequence of age.

Authors: Y H Tan; E L Chou; N Lundh
Journal: Nature Date: 1975-09-25 Impact factor: 49.962

2. THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS.

Authors: L HAYFLICK
Journal: Exp Cell Res Date: 1965-03 Impact factor: 3.905

3. Measurement of DNA content and cell volume in senescent human fibroblasts utilizing flow multiparameter single cell analysis.

Authors: E L Schneider; B J Fowlkes
Journal: Exp Cell Res Date: 1976-03-15 Impact factor: 3.905

4. Increased nuclear sizes in senescent human diploid fibroblast cultures.

Authors: Y Mitsui; E L Schneider
Journal: Exp Cell Res Date: 1976-06 Impact factor: 3.905

5. Effects of interferon on the human clonal cell line, RSa: inhibition of macromolecular synthesis.

Authors: A Fuse; T Kuwata
Journal: J Gen Virol Date: 1976-10 Impact factor: 3.891

6. Genealogies of clones of diploid fibroblasts. Cinemicrophotographic observations of cell division patterns in relation to population age.

Authors: P M Absher; R G Absher; W D Barnes
Journal: Exp Cell Res Date: 1974-09 Impact factor: 3.905

Effects of beta interferon on human fibroblasts at different population doubling levels. Proliferation, cell volume, thymidine uptake, and DNA synthesis.

1. Regulation of chromosome 21-directed anti-viral gene(s) as a consequence of age.

2. THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS.

3. Measurement of DNA content and cell volume in senescent human fibroblasts utilizing flow multiparameter single cell analysis.

4. Increased nuclear sizes in senescent human diploid fibroblast cultures.

5. Effects of interferon on the human clonal cell line, RSa: inhibition of macromolecular synthesis.

6. Genealogies of clones of diploid fibroblasts. Cinemicrophotographic observations of cell division patterns in relation to population age.

7. Clonal selection, attenuation and differentiation in an in vitro model of hyperplasia.

8. Production of high-titered interferon in cultures of human diploid cells.

9. The division cycle and RNA-synthesis in diploid human cells at different passage levels in vitro.

10. The relationship between in vitro cellular aging and in vivo human age.

1. In vivo levels and in vitro production of interferon-gamma in fibrosing interstitial lung diseases.

2. ApoHRP-based assay to measure intracellular regulatory heme.

3. The Influence of EGFR Inactivation on the Radiation Response in High Grade Glioma.