Relative potency of virulent versus avirulent Legionella pneumophila for induction of cell-mediated immunity.

Guinea pigs were infected with either high-passage, low-virulence Legionella pneumophila or low-passage, high-virulence organisms. On an infectious dosage basis, the high-virulence organisms were much more effective at sensitizing animals for positive skin test responses and splenic lymphocyte proliferation responses to homologous antigens. These results suggest that exposure to low doses of virulent L. pneumophila can effectively prime animals for cell-mediated immune responses.