Literature DB >> 335244

Legionnaires' disease: description of an epidemic of pneumonia.

D W Fraser, T R Tsai, W Orenstein, W E Parkin, H J Beecham, R G Sharrar, J Harris, G F Mallison, S M Martin, J E McDade, C C Shepard, P S Brachman.   

Abstract

An explosive, common-source outbreak of pneumonia caused by a previously unrecognized bacterium affected primarily persons attending an American Legion convention in Philadelphia in July, 1976. Twenty-nine of 182 cases were fatal. Spread of the bacterium appeared to be air borne. The source of the bacterium was not found, but epidemiologic analysis suggested that exposure may have occurred in the lobby of the headquarters hotel or in the area immediately surrounding the hotel. Person-to-person spread seemed not to have occurred. Many hotel employees appeared to be immune, suggesting that the agent may have been present in the vicinity, perhaps intermittently, for two or more years.

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Year:  1977        PMID: 335244     DOI: 10.1056/NEJM197712012972201

Source DB:  PubMed          Journal:  N Engl J Med        ISSN: 0028-4793            Impact factor:   91.245


  448 in total

1.  Intracellular growth in Acanthamoeba castellanii affects monocyte entry mechanisms and enhances virulence of Legionella pneumophila.

Authors:  J D Cirillo; S L Cirillo; L Yan; L E Bermudez; S Falkow; L S Tompkins
Journal:  Infect Immun       Date:  1999-09       Impact factor: 3.441

2.  Legionella pneumophila entry gene rtxA is involved in virulence.

Authors:  S L Cirillo; L E Bermudez; S H El-Etr; G E Duhamel; J D Cirillo
Journal:  Infect Immun       Date:  2001-01       Impact factor: 3.441

3.  A pseudo community outbreak of legionnaires' disease on Merseyside; implications for investigation of suspected clusters.

Authors:  C M Regan; Q Syed; K Mutton; B Wiratunga
Journal:  J Epidemiol Community Health       Date:  2000-10       Impact factor: 3.710

4.  In vitro interaction between normal cynolmolgus monkey alveolar macrophages and Legionnaires disease bacteria.

Authors:  R A Kishimoto; M D Kastello; J D White; F G Shirey; V G McGann; E W Larson; K W Hedlund
Journal:  Infect Immun       Date:  1979-08       Impact factor: 3.441

5.  Association Between Sporadic Legionellosis and River Systems in Connecticut.

Authors:  Kelsie Cassell; Paul Gacek; Joshua L Warren; Peter A Raymond; Matthew Cartter; Daniel M Weinberger
Journal:  J Infect Dis       Date:  2018-01-04       Impact factor: 5.226

6.  Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila.

Authors:  Christopher L Case; Sunny Shin; Craig R Roy
Journal:  Infect Immun       Date:  2009-02-23       Impact factor: 3.441

7.  Alveolar macrophages and neutrophils are the primary reservoirs for Legionella pneumophila and mediate cytosolic surveillance of type IV secretion.

Authors:  Alan M Copenhaver; Cierra N Casson; Hieu T Nguyen; Thomas C Fung; Matthew M Duda; Craig R Roy; Sunny Shin
Journal:  Infect Immun       Date:  2014-08-04       Impact factor: 3.441

8.  Confirmation of Legionella pneumophila cultures with a fluorescein-labeled monoclonal antibody.

Authors:  F C Tenover; L Carlson; L Goldstein; J Sturge; J J Plorde
Journal:  J Clin Microbiol       Date:  1985-06       Impact factor: 5.948

9.  The antibody response in Legionnaires' disease.

Authors:  J Nagington; T G Wreghitt; J O Tobin; A D Macrae
Journal:  J Hyg (Lond)       Date:  1979-10

10.  Growth of Legionella pneumophila in Acanthamoeba castellanii enhances invasion.

Authors:  J D Cirillo; S Falkow; L S Tompkins
Journal:  Infect Immun       Date:  1994-08       Impact factor: 3.441

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