Literature DB >> 6722007

Cellular X-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy.

R Weichselbaum, W Dahlberg, J B Little, T J Ervin, D Miller, S Hellman, J G Rheinwald.   

Abstract

We have investigated X-ray survival parameters and repair of potentially lethal damage ( PLDR ) in ten early passage squamous cell carcinoma cell lines derived from patients who were biopsied before initiation of radiotherapy or after radiation therapy failure. Radiosensitivity (D0) ranged from 1.07 to 1.93 (Gy), extrapolation numbers (-n) from 1.17 to 2.14 and PLD recovery at 24 h from 1.4 to 20.3. Despite significant differences in these parameters amongst the cell lines, a firm correlation between radiocurability and any individual radiobiological parameter could not be established. Our data suggest that the mechanisms associated with radioresistance are complex and that any single radiobiological parameter may not predict clinical success or failure.

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Year:  1984        PMID： 6722007      PMCID： PMC1976725          DOI： 10.1038/bjc.1984.94

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  23 in total

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Authors:  M M ELKIND; H SUTTON
Journal:  Nature       Date:  1959-10-24       Impact factor: 49.962

2.  In vitro radiation response of cells from four human tumors propagated in immune-suppressed mice.

Authors:  I E Smith; V D Courtenay; J Mills; M J Peckham
Journal:  Cancer Res       Date:  1978-02       Impact factor: 12.701

3.  In vitro and in vivo radiosensitivity of human tumour cells obtained from a pancreatic carcinoma xenograft.

Authors:  V D Courtenay; I E Smith; M J Peckham; G G Steel
Journal:  Nature       Date:  1976-10-28       Impact factor: 49.962

4.  The effects of lexA101, recB21, recF143 and uvrD3 mutations on liquid-holding recovery in ultraviolet-irradiated Escherichia coli K12 recA56.

Authors:  M S Tang; K C Smith
Journal:  Mutat Res       Date:  1981-01       Impact factor: 2.433

5.  Effects of beta-arabinofuranosyladenine on the growth and repair of potentially lethal damage in Ehrilch ascites tumor cells.

Authors:  G Iliakis
Journal:  Radiat Res       Date:  1980-09       Impact factor: 2.841

6.  In vitro cellular radiosensitivity of human malignant melanoma.

Authors:  P J Selby; V D Courtenay
Journal:  Int J Radiat Oncol Biol Phys       Date:  1982-07       Impact factor: 7.038

7.  Inhibition of X-ray-induced potentially lethal damage (PLD) repair by cordycepin (3'-deoxyadenosine) and enhancement of its action by 2'-deoxycoformycin in Chinese hamster hai cells in the stationary phase in vitro.

Authors:  S Nakatsugawa; T Sugahara
Journal:  Radiat Res       Date:  1980-11       Impact factor: 2.841

8.  Broad-shouldered survival curves of a human melanoma xenograft. Implications for radiation therapy in the absence and presence of misonidazole.

Authors:  E K Rofstad; T Brustad
Journal:  Acta Radiol Oncol       Date:  1981

9.  Tumorigenic keratinocyte lines requiring anchorage and fibroblast support cultured from human squamous cell carcinomas.

Authors:  J G Rheinwald; M A Beckett
Journal:  Cancer Res       Date:  1981-05       Impact factor: 12.701

10.  Cellular repair factors influencing radiocurability of human malignant tumours.

Authors:  R R Weichselbaum; A Schmit; J B Little
Journal:  Br J Cancer       Date:  1982-01       Impact factor: 7.640
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  9 in total

1.  A keratinocyte hypermotility/growth-arrest response involving laminin 5 and p16INK4A activated in wound healing and senescence.

Authors:  Easwar Natarajan; John D Omobono; Zongyou Guo; Susan Hopkinson; Alexander J F Lazar; Thomas Brenn; Jonathan C Jones; James G Rheinwald
Journal:  Am J Pathol       Date:  2006-06       Impact factor: 4.307

2.  Differential response of human and rodent cell lines to chemical inhibition of the repair of potentially lethal damage.

Authors:  J B Little; A M Ueno; W K Dahlberg
Journal:  Radiat Environ Biophys       Date:  1989       Impact factor: 1.925

3.  Inherently radioresistant cells exist in some human tumors.

Authors:  R R Weichselbaum; W Dahlberg; J B Little
Journal:  Proc Natl Acad Sci U S A       Date:  1985-07       Impact factor: 11.205

4.  Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head- and neck-cancer patients.

Authors:  R R Weichselbaum; W Dahlberg; M Beckett; T Karrison; D Miller; J Clark; T J Ervin
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

5.  Platinum-dye complexes inhibit repair of potentially lethal damage following bleomycin treatment.

Authors:  Y Wang; T S Herman; B A Teicher
Journal:  Br J Cancer       Date:  1989-05       Impact factor: 7.640

6.  Effect of photodynamic therapy in combination with ionizing radiation on human squamous cell carcinoma cell lines of the head and neck.

Authors:  R Allman; P Cowburn; M Mason
Journal:  Br J Cancer       Date:  2000-09       Impact factor: 7.640

7.  Platinum complexes inhibit repair of potentially lethal damage following bleomycin treatment.

Authors:  S A Holden; B A Teicher; K Boeheim; R R Weichselbaum; T J Ervin
Journal:  Br J Cancer       Date:  1987-03       Impact factor: 7.640

8.  Optical metabolic imaging of treatment response in human head and neck squamous cell carcinoma.

Authors:  Amy T Shah; Michelle Demory Beckler; Alex J Walsh; William P Jones; Paula R Pohlmann; Melissa C Skala
Journal:  PLoS One       Date:  2014-03-04       Impact factor: 3.240

9.  A Novel Peptide for Simultaneously Enhanced Treatment of Head and Neck Cancer and Mitigation of Oral Mucositis.

Authors:  Peili Chen; Maria Mancini; Stephen T Sonis; Juan Fernandez-Martinez; Jing Liu; Ezra E W Cohen; F Gary Toback
Journal:  PLoS One       Date:  2016-04-06       Impact factor: 3.240
  9 in total

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