Literature DB >> 2508186

Differential response of human and rodent cell lines to chemical inhibition of the repair of potentially lethal damage.

J B Little1, A M Ueno, W K Dahlberg.   

Abstract

We have examined the effects of several classes of metabolic inhibitors on the repair of potentially lethal damage in density-inhibited cultures of two rodent and two human cell systems which differ in their growth characteristics. Aphidicolin, 1-beta-D-arabinofuranosylcytosine (ara-C) and hydroxyurea showed no effect on PLD repair, whereas the effects of 9-beta-D-arabinofuranosyladenine (ara-A) and 3-aminobenzamide (3-AB) were cell line dependent. For example, 3-AB suppressed PLD repair almost completely in CHO cells, but showed no inhibitory effects in human diploid fibroblasts. These results indicate that inhibitors of DNA replication and poly(ADP-ribose) synthesis are not efficient inhibitors of cellular recovery in irradiated cells and, moreover, that such effects may be cell line dependent.

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Year:  1989        PMID： 2508186     DOI： 10.1007/bf01211256

Source DB:  PubMed          Journal:  Radiat Environ Biophys        ISSN： 0301-634X            Impact factor:   1.925


  23 in total

1.  Differential radiosensitization of human tumour cells by 3-aminobenzamide and benzamide: inhibitors of poly(ADP-ribosylation).

Authors:  P J Thraves; K L Mossman; T Brennan; A Dritschilo
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1986-12

2.  Repair of potentially lethal damage in vivo in solid tumor cells after x-irradiation.

Authors:  G M Hahn; S Rockwell; R F Kallman; L F Gordon; E Frindel
Journal:  Cancer Res       Date:  1974-02       Impact factor: 12.701

3.  Repair of sub-lethal and potentially lethal radiation damage in plateau phase cultures of human cells.

Authors:  J B Little
Journal:  Nature       Date:  1969-11-22       Impact factor: 49.962

4.  Deficient recovery from potentially lethal radiation damage in ataxia telengiectasia and xeroderma pigmentosum.

Authors:  R R Weichselbaum; J Nove; J B Little
Journal:  Nature       Date:  1978-01-19       Impact factor: 49.962

5.  Effects of beta-arabinofuranosyladenine on the growth and repair of potentially lethal damage in Ehrilch ascites tumor cells.

Authors:  G Iliakis
Journal:  Radiat Res       Date:  1980-09       Impact factor: 2.841

6.  3-Aminobenzamide, an inhibitor of poly(ADP-ribose) polymerase, is a stimulator, not an inhibitor, of DNA repair.

Authors:  J E Cleaver; W F Morgan
Journal:  Exp Cell Res       Date:  1987-10       Impact factor: 3.905

7.  Enhanced cell killing, inhibition of recovery from potentially lethal damage and increased mutation frequency by 3-aminobenzamide in Chinese hamster V79 cells exposed to X-rays.

Authors:  A Kumar; J Kiefer; E Schneider; N E Crompton
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1985-01

8.  Mode of action of 9-beta-D-arabinosyladenine and 1-beta-D-arabinosylcytosine on DNA synthesis in human lymphoblasts.

Authors:  D E Bell; A Fridland
Journal:  Biochim Biophys Acta       Date:  1980

9.  Influence of poly(ADP-ribose) synthesis inhibitors on the repair of sublethal and potentially lethal damage in gamma-irradiated mammalian cells.

Authors:  J Huet; F Laval
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1985-06

10.  Relationship between incorporation of 9-beta-D-arabinofuranosyladenine in L 1210 DNA and cytotoxicity.

Authors:  D W Kufe; P P Major; D Munroe; M Egan; D Herrick
Journal:  Cancer Res       Date:  1983-05       Impact factor: 12.701
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  1 in total

1.  Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition.

Authors:  Rocío Aguilar-Quesada; José Antonio Muñoz-Gámez; David Martín-Oliva; Andreína Peralta; Maria Teresa Valenzuela; Rubén Matínez-Romero; Rosa Quiles-Pérez; Josiane Menissier-de Murcia; Gilbert de Murcia; Mariano Ruiz de Almodóvar; F Javier Oliver
Journal:  BMC Mol Biol       Date:  2007-04-25       Impact factor: 2.946
  1 in total

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