Literature DB >> 6716412

Gossypol induces DNA strand breaks in human fibroblasts and sister chromatid exchanges in human lymphocytes in vitro.

M Nordenskjöld, B Lambert.   

Abstract

The male contraceptive agent gossypol was found to induce a dose related increase of DNA strand breaks in human fibroblasts in vitro at concentrations of 5 to 40 micrograms/ml. The effect was reduced in the presence of 2% fetal calf serum. A weak but reproducible increase in the SCE frequency was found in human lymphocytes treated for 1 hour in serum-free medium with 0.04 to 4 micrograms/ml of gossypol.

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Year:  1984        PMID： 6716412      PMCID： PMC1049242          DOI： 10.1136/jmg.21.2.129

Source DB:  PubMed          Journal:  J Med Genet        ISSN： 0022-2593            Impact factor:   6.318


  17 in total

1.  The rate of strand separation in alkali of DNA of irradiated mammalian cells.

Authors:  B Rydberg
Journal:  Radiat Res       Date:  1975-02       Impact factor: 2.841

2.  Gossypol--proposed contraceptive for men passes the Ames test.

Authors:  A de Peyster; Y Y Wang
Journal:  N Engl J Med       Date:  1979-08-02       Impact factor: 91.245

3.  Studies of DNA-strand induced in human fibroblasts by chemical mutagens/carcinogens.

Authors:  M Nordenskjöld; S Söderhäll; P Moldéus
Journal:  Mutat Res       Date:  1979-12       Impact factor: 2.433

4.  Non-mutagenicity of gossypol in the Salmonella/mammalian-microsome plate assay.

Authors:  N Colman; A Gardner; V Herbert
Journal:  Environ Mutagen       Date:  1979

5.  Radiation induced strand breakage in DNA from mammalian cells. Strand separation in alkaline solution.

Authors:  G Ahnström; K Erixon
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1973-03

6.  Gossypol, a powerful inhibitor of human spermatozoal metabolism.

Authors:  H Pösö; K Wichmann; J Jänne; T Luukkainen
Journal:  Lancet       Date:  1980-04-19       Impact factor: 79.321

7.  Bromodeoxyuridine-induced sister chromatid exchanges in human lymphocytes.

Authors:  B Lambert; K Hansson; J Lindsten; M Sten; B Werelius
Journal:  Hereditas       Date:  1976       Impact factor: 3.271

8.  China invents male birth control pill.

Authors:  W Wen
Journal:  Am J Chin Med       Date:  1980 Spring-Summer       Impact factor: 4.667

9.  Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange.

Authors:  P Perry; H J Evans
Journal:  Nature       Date:  1975-11-13       Impact factor: 49.962

10.  Gossypol inhibits testicular steroidogenesis.

Authors:  T Lin; E P Murono; J Osterman; H R Nankin; P B Coulson
Journal:  Fertil Steril       Date:  1981-05       Impact factor: 7.329
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