Literature DB >> 6713705

Polymorphism at the apoprotein-E locus in relation to risk of coronary disease.

A M Cumming, F W Robertson.   

Abstract

The frequency of genotypes at the polymorphic locus which codes for Apoprotein-E, an important constituent of very low density serum lipoprotein, has been determined in a random sample of persons between the ages of 45 and 60 years, born in the Grampian Region of North East Scotland. Three alleles, EII, EIII and EIV occur with a frequency of respectively 0.08, 0.77 and 0.15. In a random sample of survivors of myocardial infarction, born in the same region, genotype EIVEIII occurs more and EIIIEII less frequently than expected. Also the mean age at first infarction is lower in men for genotype EIVEIII than for other genotypes. Commonly occurring genotypes at this locus apparently influence the risk of coronary disease. A prospective study is needed to show how the genetic effects are expressed.

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Year:  1984        PMID： 6713705     DOI： 10.1111/j.1399-0004.1984.tb01995.x

Source DB:  PubMed          Journal:  Clin Genet        ISSN： 0009-9163            Impact factor:   4.438


  27 in total

Review 1.  Postprandial lipemia and coronary risk.

Authors:  W Patsch; H Esterbauer; B Föger; J R Patsch
Journal:  Curr Atheroscler Rep       Date:  2000-05       Impact factor: 5.113

2.  Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex.

Authors:  H Bickeböller; D Campion; A Brice; P Amouyel; D Hannequin; O Didierjean; C Penet; C Martin; J Pérez-Tur; A Michon; B Dubois; F Ledoze; C Thomas-Anterion; F Pasquier; M Puel; J F Demonet; O Moreaud; M C Babron; D Meulien; D Guez; M C Chartier-Harlin; T Frebourg; Y Agid; M Martinez; F Clerget-Darpoux
Journal:  Am J Hum Genet       Date:  1997-02       Impact factor: 11.025

3.  The distribution of apolipoprotein E alleles in Scottish perinatal deaths.

Authors:  J-C Becher; J W Keeling; N McIntosh; B Wyatt; J Bell
Journal:  J Med Genet       Date:  2005-09-23       Impact factor: 6.318

4.  Apolipoprotein E epsilon 4 allele is a risk factor for familial and sporadic presenile Alzheimer's disease in both homozygote and heterozygote carriers.

Authors:  D St Clair; M Rennie; E Slorach; J Norrman; C Yates; A Carothers
Journal:  J Med Genet       Date:  1995-08       Impact factor: 6.318

5.  Apolipoprotein E polymorphism influences postprandial retinyl palmitate but not triglyceride concentrations.

Authors:  E Boerwinkle; S Brown; A R Sharrett; G Heiss; W Patsch
Journal:  Am J Hum Genet       Date:  1994-02       Impact factor: 11.025

6.  An increased incidence of apolipoprotein E2/E2 and E4/E4 in retinitis pigmentosa.

Authors:  L Huq; T McLachlan; H M Hammer; D Bedford; C J Packard; J Shepherd; C A Converse
Journal:  Lipids       Date:  1993-11       Impact factor: 1.880

7.  Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E.

Authors:  M S Weintraub; S Eisenberg; J L Breslow
Journal:  J Clin Invest       Date:  1987-12       Impact factor: 14.808

8.  Gender differences in a type 2 (non-insulin-dependent) diabetic population with respect to apolipoprotein E phenotype frequencies.

Authors:  M Boemi; R W James; F Romagnoli; P Gerber; D Pometta; P Fumelli
Journal:  Diabetologia       Date:  1993-03       Impact factor: 10.122

9.  Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption.

Authors:  S H Zhang; R L Reddick; B Burkey; N Maeda
Journal:  J Clin Invest       Date:  1994-09       Impact factor: 14.808

10.  Influence of apolipoprotein E genotype on senile dementia of the Alzheimer and Lewy body types. Significance for etiological theories of Alzheimer's disease.

Authors:  C R Harrington; J Louwagie; R Rossau; E Vanmechelen; R H Perry; E K Perry; J H Xuereb; M Roth; C M Wischik
Journal:  Am J Pathol       Date:  1994-12       Impact factor: 4.307
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