Literature DB >> 6707473

Human sera possess a limited antibody repertoire to influenza neuraminidase antigenic variants selected in vitro.

A Natali, P F Panizzi, C Chezzi, J S Oxford.   

Abstract

Four antigenic variants of the neuraminidase (NA) of A/Texas/77 (H3N2) virus were selected using monoclonal antibody at a frequency of one variant in 10(5) parental virions. The antigenic variants failed to react serologically with the monoclonal antibody used for their selection in vitro. The antigenic variants failed also to react serologically with a proportion of sera from children and adults although all of the sera reacted with the parental A/Texas/77 virus. Thus, certain human sera have a restricted antibody repertoire to influenza NA antigen which might enable virus antigenic variants to avoid anti-NA antibody-mediated neutralization in nature.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6707473      PMCID： PMC2129242          DOI： 10.1017/s0022172400064263

Source DB:  PubMed          Journal:  J Hyg (Lond)        ISSN： 0022-1724


  20 in total

1.  Polypeptides specified by the influenza virus genome I. Evidence for eight distinct gene products specified by fowl plague virus.

Authors:  S C Inglis; A R Carroll; R A Lamb; B W Mahy
Journal:  Virology       Date:  1976-10-15       Impact factor: 3.616

2.  The assay of influenza antineuraminidase activity by an elution inhibition technique.

Authors:  G Appleyard; J D Oram
Journal:  J Gen Virol       Date:  1977-01       Impact factor: 3.891

3.  Influenzavirus neuraminidase and neuraminidase-inhibition test procedures.

Authors:  M Aymard-Henry; M T Coleman; W R Dowdle; W G Laver; G C Schild; R G Webster
Journal:  Bull World Health Organ       Date:  1973       Impact factor: 9.408

4.  Serological relationships between the neuraminidases in influenza viruses.

Authors:  C K Paniker
Journal:  J Gen Virol       Date:  1968-05       Impact factor: 3.891

5.  Single-radial-hemolysis: a new method for the assay of antibody to influenza haemagglutinin. Applications for diagnosis and seroepidemiologic surveillance of influenza.

Authors:  G C Schild; M S Pereira; P Chakraverty
Journal:  Bull World Health Organ       Date:  1975       Impact factor: 9.408

6.  Functional significance of sialidose during influenza virus multiplication.

Authors:  J T Seto; R Rott
Journal:  Virology       Date:  1966-12       Impact factor: 3.616

7.  Antiviral activity of antiserum specific for an influenza virus neuraminidase.

Authors:  E D Kilbourne; W G Laver; J L Schulman; R G Webster
Journal:  J Virol       Date:  1968-04       Impact factor: 5.103

8.  Antigenic variants of influenza A virus obtained in vitro.

Authors:  L R Haaheim; G C Schild
Journal:  Bull World Health Organ       Date:  1976       Impact factor: 9.408

9.  Reduction in plaque size and reduction in plaque number as differing indices of influenza virus-antibody reactions.

Authors:  R I Jahiel; E D Kilbourne
Journal:  J Bacteriol       Date:  1966-11       Impact factor: 3.490

10.  Production of antibodies against influenza virus by somatic cell hybrids between mouse myeloma and primed spleen cells.

Authors:  H Koprowski; W Gerhard; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205
View more
  1 in total

1.  Defining influenza A virus hemagglutinin antigenic drift by sequential monoclonal antibody selection.

Authors:  Suman R Das; Scott E Hensley; William L Ince; Christopher B Brooke; Anju Subba; Mark G Delboy; Gustav Russ; James S Gibbs; Jack R Bennink; Jonathan W Yewdell
Journal:  Cell Host Microbe       Date:  2013-03-13       Impact factor: 21.023
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.