Literature DB >> 6707229

Serum paraproteins in chronic lymphocytic leukaemia.

D Sinclair, J H Dagg, A M Mowat, D M Parrott, D I Stott.   

Abstract

The presence of paraproteins in the sera of 10 patients with chronic lymphocytic leukaemia (CLL) was investigated using immunoisoelectric focusing. Monoclonal immunoglobulins were found in nine of these 10 sera. Five sera contained a single monoclonal IgM paraprotein, one serum contained a single monoclonal IgG paraprotein, while three sera contained more than one monoclonal paraprotein--namely, IgM + IgD, IgM + IgG, and IgM + IgD + IgG. The results indicate that the malignant B cells of CLL may be at a later stage of differentiation than previously assumed and serum monoclonal immunoglobulin could be of value as a tumour marker.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6707229      PMCID： PMC498753          DOI： 10.1136/jcp.37.4.463

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  8 in total

1.  Clinical staging of chronic lymphocytic leukemia.

Authors:  K R Rai; A Sawitsky; E P Cronkite; A D Chanana; R N Levy; B S Pasternack
Journal:  Blood       Date:  1975-08       Impact factor: 22.113

Review 2.  Differentiation capacity and other properties of the leukemic cells of chronic lymphocytic leukemia.

Authors:  S M Fu; N Chiorazzi; H G Kunkel
Journal:  Immunol Rev       Date:  1979       Impact factor: 12.988

Review 3.  Chronic lymphocytic leukaemia and its relationship to other lymphoproliferative disorders.

Authors:  D L Sweet; H M Golomb; J E Ultmann
Journal:  Clin Haematol       Date:  1977-02

4.  The application of isoelectric focusing to routine screening for paraproteinaemia.

Authors:  D Sinclair; D S Kumararatne; J B Forrester; A Lamont; D I Stott
Journal:  J Immunol Methods       Date:  1983-11-11       Impact factor: 2.303

5.  Monoclonal macroglobulinemia in malignant lymphoma.

Authors:  D F Moore; P J Migliore; C C Shullenberger; R Alexanian
Journal:  Ann Intern Med       Date:  1970-01       Impact factor: 25.391

6.  Monoclonal gammopathy in lymphoma.

Authors:  R Alexanian
Journal:  Arch Intern Med       Date:  1975-01

7.  Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation.

Authors:  E C Butcher; R V Rouse; R L Coffman; C N Nottenburg; R R Hardy; I L Weissman
Journal:  J Immunol       Date:  1982-12       Impact factor: 5.422

8.  Extracellular idiotypic immunoglobulin arising from human leukemic B lymphocytes.

Authors:  F K Stevenson; T J Hamblin; G T Stevenson; A L Tutt
Journal:  J Exp Med       Date:  1980-12-01       Impact factor: 14.307
  8 in total
  2 in total

Review 1.  Immunoblotting and dot blotting.

Authors:  D I Stott
Journal:  J Immunol Methods       Date:  1989-05-12       Impact factor: 2.303

2.  Association of elevated serumfree light chains with chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis.

Authors:  Alyssa I Clay-Gilmour; Abdul R Rishi; Lynn R Goldin; Alexandra J Greenberg-Worisek; Sara J Achenbach; Kari G Rabe; Matthew J Maurer; Neil E Kay; Tait D Shanafelt; Timothy G Call; J Brice Weinberg; Nicola J Camp; James R Cerhan; Jose Leis; Aaron Norman; David L Murray; S Vincent Rajkumar; Neil E Caporaso; Ola Landgren; Mary L McMaster; Susan L Slager; Celine M Vachon
Journal:  Blood Cancer J       Date:  2019-08-05       Impact factor: 11.037
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.