Literature DB >> 6644030

The application of isoelectric focusing to routine screening for paraproteinaemia.

D Sinclair, D S Kumararatne, J B Forrester, A Lamont, D I Stott.   

Abstract

We present a scheme for routine screening of patients' sera for monoclonal immunoglobulin by isoelectric focusing in agarose gels. Using this method combined with immunofixation, we have been able to detect monoclonal immunoglobulin in the sera of patients, and to identify the isotype of the immunoglobulin when conventional techniques such as zonal and immunoelectrophoresis have yielded equivocal results.

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Year:  1983        PMID： 6644030     DOI： 10.1016/0022-1759(83)90393-9

Source DB:  PubMed          Journal:  J Immunol Methods        ISSN： 0022-1759            Impact factor:   2.303


  6 in total

1.  Demonstration of serum monoclonal immunoglobulin in a case of non-secretory myeloma by immunoisoelectric focusing.

Authors:  T Sheehan; D Sinclair; P Tansey; J R O'Donnell
Journal:  J Clin Pathol       Date:  1985-07       Impact factor: 3.411

2.  Serum paraproteins in chronic lymphocytic leukaemia.

Authors:  D Sinclair; J H Dagg; A M Mowat; D M Parrott; D I Stott
Journal:  J Clin Pathol       Date:  1984-04       Impact factor: 3.411

3.  Homogeneous immunoglobulins in the sera of lung carcinoma patients receiving cytotoxic chemotherapy--detection with the use of isoelectric focusing and immunoblotting.

Authors:  H Haas; A Lange; M Schlaak
Journal:  Clin Exp Immunol       Date:  1987-12       Impact factor: 4.330

4.  Detection and identification of serum monoclonal immunoglobulin by immunoisoelectric focusing. Limits of sensitivity and use during relapse of multiple myeloma.

Authors:  D Sinclair; D S Kumararatne; D Stott
Journal:  J Clin Pathol       Date:  1984-03       Impact factor: 3.411

5.  Analysis of the clonal origins of autoantibodies against thyroglobulin and DNA in autoimmune thyroiditis and systemic lupus erythematosus.

Authors:  D I Stott; J McLearie; L Neilson
Journal:  Clin Exp Immunol       Date:  1986-09       Impact factor: 4.330

Review 6.  Immunoblotting and dot blotting.

Authors:  D I Stott
Journal:  J Immunol Methods       Date:  1989-05-12       Impact factor: 2.303
  6 in total

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