Literature DB >> 6702512

Decreased vascular sensitivity to histamine during aging.

C Brink, P G Duncan, J S Douglas.   

Abstract

The sensitivity of thoracic aorta preparations to histamine decreased with age. The responsiveness to histamine was unchanged. Indomethacin (17 microM) did not affect the basal tone of preparations from either young or old guinea pigs nor did the drug alter aortic sensitivity or responsiveness to histamine. The data show that (a) changes in vascular sensitivity to histamine during aging are not due to prostaglandins and that (b) prostaglandins do not act locally to modulate vascular tissue response to histamine.

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Year:  1984        PMID： 6702512     DOI： 10.1007/bf01966826

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  10 in total

1.  Differences in the effects of transmitters on smooth muscles from adult and young guinea pigs and rats.

Authors:  V Petkov; S Todorov; E Kitova
Journal:  Agressologie       Date:  1975

2.  Prostaglandin regulation of airway smooth muscle tone.

Authors:  J Orehek; J S Douglas; A J Lewis; A Bouhuys
Journal:  Nat New Biol       Date:  1973-09-19

3.  The effect of age on -adrenoceptor activity in tracheal smooth muscle.

Authors:  G Aberg; G Adler
Journal:  Br J Pharmacol       Date:  1973-01       Impact factor: 8.739

4.  Ontogeny of aortic PGI2 formation in the developing spontaneously hypertensive rat--correlation with elevations in blood pressure.

Authors:  C R Pace-Asciak; M C Carrara
Journal:  Adv Prostaglandin Thromboxane Res       Date:  1980

5.  Changes in responsiveness of the heart to drugs during aging.

Authors:  J Roberts; P B Goldberg
Journal:  Fed Proc       Date:  1979-04

6.  Response and sensitivity of female guinea-pig respiratory tissues to agonists during ontogenesis.

Authors:  C Brink; P G Duncan; M Midzenski; J S Douglas
Journal:  J Pharmacol Exp Ther       Date:  1980-11       Impact factor: 4.030

7.  The relationship between age and relaxation of vascular smooth muscle in the rabbit and rat.

Authors:  J H Fleisch; C S Hooker
Journal:  Circ Res       Date:  1976-04       Impact factor: 17.367

8.  Further studies on the effect of ageing on beta-adrenoceptor activity of rat aorta.

Authors:  J H Fleisch
Journal:  Br J Pharmacol       Date:  1971-06       Impact factor: 8.739

9.  Age-dependent alteration in the response of isolated rabbit basilar arteries to vasoactive agents.

Authors:  N Toda; S Hayashi
Journal:  J Pharmacol Exp Ther       Date:  1979-12       Impact factor: 4.030

10.  Sarcoplasmic reticulum and excitation-contraction coupling in mammalian smooth muscles.

Authors:  C E Devine; A V Somlyo; A P Somlyo
Journal:  J Cell Biol       Date:  1972-03       Impact factor: 10.539
  10 in total
  1 in total

1.  Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes.

Authors:  R Bucala; K J Tracey; A Cerami
Journal:  J Clin Invest       Date:  1991-02       Impact factor: 14.808
  1 in total

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