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Literature DB >> 6701090

Diadenosine 5',5'"-P1,P4-tetraphosphate in developing embryos of Artemia.

Abstract

Diadenosine 5',5'"-P1,P4-tetraphosphate (Ap4A) has been detected in cysts and developing embryos of the brine shrimp Artemia in amounts 10(4)-10(6) times lower than that of the guanine analogue, Gp4G. The unexpectedly high level of Ap4A in dormant cysts of 2.37 pmol/10(6) cells can be reduced to 0.03 pmol/10(6) cells by decapsulation and storage in saturated NaCl. When development is reinitiated, the Ap4A content of the decapsulated embryos undergoes a rapid 125 -fold increase, reaching a maximum of 3.79 pmol/10(6) cells at the point of emergence when DNA replication begins. If replication is delayed by hypoxia, the Ap4A level is adjusted in order to reach the same maximum value when replication finally begins. As replication proceeds, the level of Ap4A declines again. Unlike mammalian cells, Ap4A in Artemia is less metabolically labile than ATP. These results are consistent with the suggested role of Ap4A in the initiation of DNA synthesis.

Entities: Chemical Disease Species

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Year: 1984 PMID： 6701090 PMCID： PMC318602 DOI： 10.1093/nar/12.3.1609

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

31 in total

1. Presence of diadenosine 5',5''' -P1, P4-tetraphosphate (Ap4A) in mamalian cells in levels varying widely with proliferative activity of the tissue: a possible positive "pleiotypic activator".

Authors: E Rapaport; P C Zamecnik
Journal: Proc Natl Acad Sci U S A Date: 1976-11 Impact factor: 11.205

2. Interrelationships between water and cellular metabolism in Artemia cysts. IV. Adenosine 5'-triphosphate and cyst hydration.

Authors: J S Clegg; J Cavagnaro
Journal: J Cell Physiol Date: 1976-06 Impact factor: 6.384

3. The use of Artemia salina for developmental studies: preparation of embryos, tRNA, ribosomes and initiation factor 2.

Authors: A H Warner; T H MacRae; A J Wahba
Journal: Methods Enzymol Date: 1979 Impact factor: 1.600

4. Diguanosinetetraphosphate guanylohydrolase in Artemia salina.

Authors: C G Vallejo; M A Sillero; A Sillero
Journal: Biochim Biophys Acta Date: 1974-07-17

5. An unusual pathway for the synthesis of adenosine triphosphate by the purine-requiring organism Artemia salina.

Authors: G Van Denbos; F J Finamore
Journal: J Biol Chem Date: 1974-05-10 Impact factor: 5.157

6. Diadenosine tetraphosphate triggers in vitro DNA replication.

Authors: F Grummt
Journal: Cold Spring Harb Symp Quant Biol Date: 1979

7. A fixed site of DNA replication in eucaryotic cells.

Authors: D M Pardoll; B Vogelstein; D S Coffey
Journal: Cell Date: 1980-02 Impact factor: 41.582

8. Diadenosine 5',5'''-P1,P4-tetraphosphate, a ligand of the 57-kilodalton subunit of DNA polymerase alpha.

Authors: F Grummt; G Waltl; H M Jantzen; K Hamprecht; U Huebscher; C C Kuenzle
Journal: Proc Natl Acad Sci U S A Date: 1979-12 Impact factor: 11.205

9. Diadenosine 5',5'''-P1,P4-tetraphosphate triggers initiation of in vitro DNA replication in baby hamster kidney cells.

Authors: F Grummt
Journal: Proc Natl Acad Sci U S A Date: 1978-01 Impact factor: 11.205

10. Zinc(II)-dependent synthesis of diadenosine 5', 5"' -P(1) ,P(4) -tetraphosphate by Escherichia coli and yeast phenylalanyl transfer ribonucleic acid synthetases.

Authors: P Plateau; J F Mayaux; S Blanquet
Journal: Biochemistry Date: 1981-08-04 Impact factor: 3.162

13 in total

1. Ca(2+)-stores mobilization by diadenosine tetraphosphate, Ap4A, through a putative P2Y purinoceptor in adrenal chromaffin cells.

Authors: E Castro; J Pintor; M T Miras-Portugal
Journal: Br J Pharmacol Date: 1992-08 Impact factor: 8.739

2. Metabolism of adenylylated nucleotides in Clostridium acetobutylicum.

Authors: I A Balodimos; E R Kashket; E Rapaport
Journal: J Bacteriol Date: 1988-05 Impact factor: 3.490

3. SARS coronavirus protein 7a interacts with human Ap4A-hydrolase.

Authors: Natalia Vasilenko; Igor Moshynskyy; Alexander Zakhartchouk
Journal: Virol J Date: 2010-02-09 Impact factor: 4.099

4. Isolation, characterization, and inactivation of the APA1 gene encoding yeast diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase.

Authors: P Plateau; M Fromant; J M Schmitter; J M Buhler; S Blanquet
Journal: J Bacteriol Date: 1989-12 Impact factor: 3.490

5. The gene for Escherichia coli diadenosine tetraphosphatase is located immediately clockwise to folA and forms an operon with ksgA.

Authors: S Blanchin-Roland; S Blanquet; J M Schmitter; G Fayat
Journal: Mol Gen Genet Date: 1986-12

6. Synthesis and resistance to enzymic hydrolysis of stereochemically-defined phosphonate and thiophosphate analogues of P1,P4-bis(5'-adenosyl) tetraphosphate.

Authors: G M Blackburn; G E Taylor; G R Thatcher; M Prescott; A G McLennan
Journal: Nucleic Acids Res Date: 1987-09-11 Impact factor: 16.971

7. Changes in intracellular levels of Ap3A and Ap4A in cysts and larvae of Artemia do not correlate with changes in protein synthesis after heat-shock.

Authors: D Miller; A G McLennan
Journal: Nucleic Acids Res Date: 1986-08-11 Impact factor: 16.971

8. In vivo levels of diadenosine tetraphosphate and adenosine tetraphospho-guanosine in Physarum polycephalum during the cell cycle and oxidative stress.

Authors: P N Garrison; S A Mathis; L D Barnes
Journal: Mol Cell Biol Date: 1986-04 Impact factor: 4.272

9. Cell cycle variations of dinucleoside polyphosphates in synchronized cultures of mammalian cells.

Authors: G Orfanoudakis; M Baltzinger; D Meyer; N Befort; J P Ebel; J J Befort; P Remy
Journal: Mol Cell Biol Date: 1987-07 Impact factor: 4.272

10. Chemical modification of a functional arginine residue in diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) phosphorylase I from Saccharomyces cerevisiae.

Authors: A K Robinson; L D Barnes
Journal: Biochem J Date: 1991-10-01 Impact factor: 3.857