Aspects of the epidemiology of Crohn's disease in the Jewish population in Beer Sheva, Israel.

The epidemiology of Crohn's disease in Jews in the Beer Sheva district of Israel was studied. The mean annual incidence per 10(5) population was 1.1 for the period 1961-80 and 1.8 for the period 1976-80. The crude prevalence rate on 31 December 1980 was 14.0 per 10(5) population. The unadjusted prevalence rates by place of birth were: Israeli-born 6.9, European/American-born 24.6 and Asian/African-born 19.4 per 10(5) population. The age-adjusted prevalence rates were: Israeli-born 9.7, European/American-born 15.8 and Asian/African-born 12.5 per 10(5) population. The study has demonstrated: 1) that Crohn's disease has a low prevalence in Jews in this district; 2) that Crohn's disease is not as uncommon in Asian/African-born Jews as was previously thought; 3) that the low crude rate of Crohn's disease in Israeli-born Jews in this district is partially accounted for by the age distribution of the population; and 4) that environmental rather than genetic factors appear to determine the incidence of Crohn's disease in this district.