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Literature DB >> 24574798

Epidemiological studies of migration and environmental risk factors in the inflammatory bowel diseases.

Yanna Ko¹, Rhys Butcher¹, Rupert W Leong¹.

Abstract

Inflammatory bowel diseases (IBD) are idiopathic chronic diseases of the gastrointestinal tract well known to be associated with both genetic and environmental risk factors. Permissive genotypes may manifest into clinical phenotypes under certain environmental influences and these may be best studied from migratory studies. Exploring differences between first and second generation migrants may further highlight the contribution of environmental factors towards the development of IBD. There are few opportunities that have been offered so far. We aim to review the available migration studies on IBD, evaluate the known environmental factors associated with IBD, and explore modern migration patterns to identify new opportunities and candidate migrant groups in IBD migration research.

Entities: Disease

Keywords: Crohn’s disease; Environment; Epidemiology; Hygiene hypothesis; Inflammatory bowel disease; Risk factor; Ulcerative colitis

Mesh：

Year: 2014 PMID： 24574798 PMCID： PMC3921506 DOI： 10.3748/wjg.v20.i5.1238

Source DB: PubMed Journal: World J Gastroenterol ISSN： 1007-9327 Impact factor: 5.742

73 in total

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20 in total

1. LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn's disease patients.

Authors: Ta-Chiang Liu; Takeo Naito; Zhenqiu Liu; Kelli L VanDussen; Talin Haritunians; Dalin Li; Katsuya Endo; Yosuke Kawai; Masao Nagasaki; Yoshitaka Kinouchi; Dermot Pb McGovern; Tooru Shimosegawa; Yoichi Kakuta; Thaddeus S Stappenbeck
Journal: JCI Insight Date: 2017-03-23

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Authors: Laura J Dixon; Amrita Kabi; Kourtney P Nickerson; Christine McDonald
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Authors: Ashwin N Ananthakrishnan; Hamed Khalili; Mingyang Song; Leslie M Higuchi; Paul Lochhead; James M Richter; Andrew T Chan
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