Literature DB >> 6696751

Inactivation of betaine-homocysteine methyltransferase by adenosylmethionine and adenosylethionine.

J D Finkelstein, J J Martin.   

Abstract

Preincubation of betaine-homocysteine methyltransferase, prepared from rat liver, with either S-adenosylmethionine or S-adenosylethionine results in a marked loss of enzyme activity. Gel filtration did not restore activity. However both S-adenosylhomocysteine and L-homocysteine, when added to the preincubation medium, inhibited the inactivation of betaine-homocysteine methyltransferase.

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Year:  1984        PMID： 6696751     DOI： 10.1016/0006-291x(84)91060-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  13 in total

1.  Metabolite and gene expression profiles suggest a putative mechanism through which high dietary carbohydrates reduce the content of hepatic betaine in Megalobrama amblycephala.

Authors:  Jia Xu; Fan Wang; Ivan Jakovlić; Wassana Prisingkorn; Jun-Tao Li; Wei-Min Wang; Yu-Hua Zhao
Journal:  Metabolomics       Date:  2018-07-04       Impact factor: 4.290

2.  Increased sensitivity to oxidative injury in chinese hamster ovary cells stably transfected with rat liver S-adenosylmethionine synthetase cDNA.

Authors:  E Sánchez-Góngora; J G Pastorino; L Alvarez; M A Pajares; C García; J R Viña; J M Mato; J L Farber
Journal:  Biochem J       Date:  1996-11-01       Impact factor: 3.857

3.  Folic acid mitigated cardiac dysfunction by normalizing the levels of tissue inhibitor of metalloproteinase and homocysteine-metabolizing enzymes postmyocardial infarction in mice.

Authors:  Natia Qipshidze; Neetu Tyagi; Utpal Sen; Srikanth Givvimani; Naira Metreveli; David Lominadze; Suresh C Tyagi
Journal:  Am J Physiol Heart Circ Physiol       Date:  2010-08-27       Impact factor: 4.733

4.  The smooth muscle relaxant effect of hydrogen sulphide in vitro: evidence for a physiological role to control intestinal contractility.

Authors:  B Teague; S Asiedu; P K Moore
Journal:  Br J Pharmacol       Date:  2002-09       Impact factor: 8.739

5.  S-Adenosyl-l-ethionine is a Catalytically Competent Analog of S-Adenosyl-l-methione (SAM) in the Radical SAM Enzyme HydG.

Authors:  Stella Impano; Hao Yang; Eric M Shepard; Ryan Swimley; Adrien Pagnier; William E Broderick; Brian M Hoffman; Joan B Broderick
Journal:  Angew Chem Int Ed Engl       Date:  2020-12-01       Impact factor: 15.336

6.  Mathematical analysis of the regulation of competing methyltransferases.

Authors:  Michael C Reed; Mary V Gamble; Megan N Hall; H Frederik Nijhout
Journal:  BMC Syst Biol       Date:  2015-10-14

7.  Maternal Folate Status and the BHMT c.716G>A Polymorphism Affect the Betaine Dimethylglycine Pathway during Pregnancy.

Authors:  Jose M Colomina; Pere Cavallé-Busquets; Sílvia Fernàndez-Roig; Pol Solé-Navais; Joan D Fernandez-Ballart; Mónica Ballesteros; Per M Ueland; Klaus Meyer; Michelle M Murphy
Journal:  Nutrients       Date:  2016-10-09       Impact factor: 5.717

8.  Choline and methionine differentially alter methyl carbon metabolism in bovine neonatal hepatocytes.

Authors:  Tawny L Chandler; Heather M White
Journal:  PLoS One       Date:  2017-02-02       Impact factor: 3.240

Review 9.  Alterations of methionine metabolism in hepatocarcinogenesis: the emergent role of glycine N-methyltransferase in liver injury.

Authors:  Maria M Simile; Gavinella Latte; Claudio F Feo; Francesco Feo; Diego F Calvisi; Rosa M Pascale
Journal:  Ann Gastroenterol       Date:  2018-07-12

10.  Quercetin Increases Hepatic Homocysteine Remethylation and Transsulfuration in Rats Fed a Methionine-Enriched Diet.

Authors:  Bin Meng; Weina Gao; Jingyu Wei; Lingling Pu; Zhenchuang Tang; Changjiang Guo
Journal:  Biomed Res Int       Date:  2015-10-19       Impact factor: 3.411
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