Literature DB >> 6694100

Relationship between renal clearance, protein binding and urine flow for digitoxin, a compound of low clearance in the isolated perfused rat kidney.

S Hall, M Rowland.   

Abstract

An isolated perfused rat kidney preparation is described which allows the relationship between protein binding and renal clearance to be studied in a quantitative manner. The influence of unbound fraction of drug in the perfusate, urine pH and urine flow upon the renal clearance of digitoxin is examined. Renal clearance and unbound fraction were found to be related linearly. Urine pH did not influence digitoxin renal clearance but urine flow did, in a nonlinear manner. A simple physiologically based model of renal clearance is developed which predicts the influence of urine flow and protein binding upon digitoxin clearance in this preparation.

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Year:  1984        PMID： 6694100

Source DB:  PubMed          Journal:  J Pharmacol Exp Ther        ISSN： 0022-3565            Impact factor:   4.030


  11 in total

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Authors:  Melanie A Felmlee; Rutwij A Dave; Marilyn E Morris
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4.  Protein binding and drug clearance.

Authors:  M Rowland
Journal:  Clin Pharmacokinet       Date:  1984-01       Impact factor: 6.447

5.  Mechanistic toxicokinetic model for gamma-hydroxybutyric acid: inhibition of active renal reabsorption as a potential therapeutic strategy.

Authors:  Melanie A Felmlee; Qi Wang; Dapeng Cui; Samuel A Roiko; Marilyn E Morris
Journal:  AAPS J       Date:  2010-05-12       Impact factor: 4.009

Review 6.  Protein binding as a primary determinant of the clinical pharmacokinetic properties of non-steroidal anti-inflammatory drugs.

Authors:  J H Lin; D M Cocchetto; D E Duggan
Journal:  Clin Pharmacokinet       Date:  1987-06       Impact factor: 6.447

Review 7.  Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part II: Mechanistic Models and In Vitro-In Vivo Extrapolation.

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Journal:  AAPS J       Date:  2016-08-09       Impact factor: 4.009

8.  In vivo interaction of the enantiomers of disopyramide in human subjects.

Authors:  K M Giacomini; W L Nelson; R A Pershe; L Valdivieso; K Turner-Tamiyasu; T F Blaschke
Journal:  J Pharmacokinet Biopharm       Date:  1986-08

9.  Semi-mechanistic kidney model incorporating physiologically-relevant fluid reabsorption and transporter-mediated renal reabsorption: pharmacokinetics of γ-hydroxybutyric acid and L-lactate in rats.

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Journal:  J Pharmacokinet Pharmacodyn       Date:  2015-09-04       Impact factor: 2.745

Review 10.  Drug structure-transport relationships.

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Journal:  J Pharmacokinet Pharmacodyn       Date:  2010-11-24       Impact factor: 2.745
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