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Literature DB >> 6692924

Effects of hypothyroidism on myosin isozyme transitions in developing rat muscle.

G S Butler-Browne, D Herlicoviez, R G Whalen.

Abstract

Hypothyroidism was induced in young rats by methylthiouracil treatment of pregnant mothers from 18 days of gestation to 4 weeks after birth. Electrophoretic analysis of native myosin isozymes revealed a persistence of neonatal and embryonic myosin in developing fast and slow muscles up to at least 28 days after birth. The appearance of adult fast myosin was inhibited in 28-day old animals, however adult slow myosin was found in the soleus muscle. Immunocytochemical results on the soleus demonstrate a cellular heterogeneity in the response to hypothyroidism. About half fibers have a normal complement of slow myosin and do not contain neonatal myosin. Only the remaining fibers contain the large amounts of neonatal myosin demonstrated by electrophoresis.

Entities: Chemical Disease Species

Mesh：

Substances：
Isoenzymes
Myosins

Year: 1984 PMID： 6692924 DOI： 10.1016/0014-5793(84)80047-2

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

23 in total

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Journal: Gene Expr Date: 1992

2. Identification of and pattern of transitions of cardiac, adult slow and slow skeletal muscle-like embryonic isoforms of troponin T in developing rat and human skeletal muscles.

Authors: M A Sabry; G K Dhoot
Journal: J Muscle Res Cell Motil Date: 1991-06 Impact factor: 2.698

3. Effects of hypothyroidism on myosin heavy chain composition and fibre types of fast skeletal muscles in a small marsupial, Antechinus flavipes.

Authors: Wendy W H Zhong; Kerry W Withers; Joseph F Y Hoh
Journal: J Comp Physiol B Date: 2009-12-11 Impact factor: 2.200

4. Natural involution of muscle in the proximal sesamoidean ligament in sheep.

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Journal: J Anat Date: 1995-02 Impact factor: 2.610

5. The effect of nutrition on the size and proportion of muscle fibre types during growth.

Authors: A Yamaguchi; Y Horio; K Sakuma; S Katsuta
Journal: J Anat Date: 1993-02 Impact factor: 2.610

6. Activation of myoD gene transcription by 3,5,3'-triiodo-L-thyronine: a direct role for the thyroid hormone and retinoid X receptors.

Authors: G E Muscat; L Mynett-Johnson; D Dowhan; M Downes; R Griggs
Journal: Nucleic Acids Res Date: 1994-02-25 Impact factor: 16.971

Effects of hypothyroidism on myosin isozyme transitions in developing rat muscle.

1. Four sarcomeric myosin heavy chain genes are expressed by human fetal skeletal muscle cells differentiating in culture.

2. Identification of and pattern of transitions of cardiac, adult slow and slow skeletal muscle-like embryonic isoforms of troponin T in developing rat and human skeletal muscles.

3. Effects of hypothyroidism on myosin heavy chain composition and fibre types of fast skeletal muscles in a small marsupial, Antechinus flavipes.

4. Natural involution of muscle in the proximal sesamoidean ligament in sheep.

5. The effect of nutrition on the size and proportion of muscle fibre types during growth.

6. Activation of myoD gene transcription by 3,5,3'-triiodo-L-thyronine: a direct role for the thyroid hormone and retinoid X receptors.

Review 7. Thyroid Hormone Signalling: From the Dawn of Life to the Bedside.

8. Thyroid Hormone Signaling in Muscle Development, Repair and Metabolism.

9. Unusual fast myosin isozyme pattern in the lateral gastrocnemius of the chicken.

10. The time course of thyroid-hormone-induced changes in the isotonic and isometric properties of rat soleus muscle.