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Literature DB >> 6688207

Methimazole inhibits thyroid autoantibody production by an action on accessory cells.

Abstract

It is now possible to demonstrate production of thyroglobulin antibodies by Hashimoto lymphocytes when they are cultured with autologous thyroglobulin-primed accessory cells. When accessory cells are primed with antigen in the presence of the antithyroid drug methimazole, antibody production is blocked. This finding suggests that the immunosuppressive action of this group of antithyroid drugs is mediated by an action on antigen handling by accessory cells.

Entities: Chemical

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Year: 1983 PMID： 6688207 DOI： 10.1016/0090-1229(83)90186-1

Source DB: PubMed Journal: Clin Immunol Immunopathol ISSN： 0090-1229

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Cited

16 in total

1. Graves' disease and Hashimoto's thyroiditis: effects of high doses of antithyroid drugs on thyroid autoantibody levels.

Authors: J H Romaldini; M C Werner; H F Rodrigues; V L Teixeira; R S Werner; C S Farah; N Bromberg
Journal: J Endocrinol Invest Date: 1986-06 Impact factor: 4.256

2. Thyroid stimulating immunoglobulin (TSI) synthesis by pokeweed mitogen (PWM) stimulated peripheral blood lymphocytes (PBL) from Graves' disease (GD) patients.

Authors: B Pautard; J J Rémy; J Charreire
Journal: Clin Exp Immunol Date: 1986-11 Impact factor: 4.330

9. Effect of carbimazole treatment on specific and non-specific immunological parameters in patients with Graves' disease.

Authors: J Charreire; G Karsenty; P Bouchard; G Schaison
Journal: Clin Exp Immunol Date: 1984-09 Impact factor: 4.330

10. The T cell suppressor defect in autoimmune thyroiditis: evidence for a high set 'autoimmunostat'.

Authors: T F Davies; M Platzer
Journal: Clin Exp Immunol Date: 1986-01 Impact factor: 4.330

Methimazole inhibits thyroid autoantibody production by an action on accessory cells.

1. Graves' disease and Hashimoto's thyroiditis: effects of high doses of antithyroid drugs on thyroid autoantibody levels.

2. Thyroid stimulating immunoglobulin (TSI) synthesis by pokeweed mitogen (PWM) stimulated peripheral blood lymphocytes (PBL) from Graves' disease (GD) patients.

3. Are antithyroid drugs immunosuppressive?

4. Methimazole and generation of oxygen radicals by monocytes: potential role in immunosuppression.

Review 5. An update on the medical treatment of Graves' hyperthyroidism.

6. Analysis of T cell subsets in Graves' disease: alterations associated with carbimazole.

7. Methimazole and generation of oxygen radicals by monocytes: potential role in immunosuppression.

8. Thyroglobulin uptake and presentation by macrophages in experimental autoimmune thyroiditis.

9. Effect of carbimazole treatment on specific and non-specific immunological parameters in patients with Graves' disease.

10. The T cell suppressor defect in autoimmune thyroiditis: evidence for a high set 'autoimmunostat'.