Literature DB >> 6421361

Methimazole and generation of oxygen radicals by monocytes: potential role in immunosuppression.

A P Weetman, M E Holt, A K Campbell, R Hall, A M McGregor.   

Abstract

A study was conducted investigating the possibility that the immunosuppressive action of methimazole (the active metabolite of the antithyroid drug carbimazole) might be due to an effect on the production of oxygen radicals by monocytes. Techniques comprised measurement of luminol dependent chemoluminescence in monocytes and a spectrophotometric assay for production of hydrogen peroxide. The results showed definite inhibition of formation of oxygen radicals by resting and stimulated monocytes, which may explain the immunosuppressive action of the drug in Graves' disease. The findings also suggest that the formation of oxygen radicals and the initiation of the immune response may be closely related.

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Year:  1984        PMID： 6421361      PMCID： PMC1444568          DOI： 10.1136/bmj.288.6416.518

Source DB:  PubMed          Journal:  Br Med J (Clin Res Ed)        ISSN： 0267-0623


  14 in total

1.  Oxygen-dependent microbial killing by phagocytes (first of two parts).

Authors:  B M Babior
Journal:  N Engl J Med       Date:  1978-03-23       Impact factor: 91.245

2.  Secretion of oxygen intermediates: role in effector functions of activated macrophages.

Authors:  C F Nathan
Journal:  Fed Proc       Date:  1982-04

3.  Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions.

Authors:  J C Fantone; P A Ward
Journal:  Am J Pathol       Date:  1982-06       Impact factor: 4.307

4.  The subcellular distribution and some properties of the cytochrome b component of the microbicidal oxidase system of human neutrophils.

Authors:  A W Segal; O T Jones
Journal:  Biochem J       Date:  1979-07-15       Impact factor: 3.857

5.  Accumulation of 2-[14C]propylthiouracil in human polymorphonuclear leukocytes.

Authors:  D C Lam; R H Lindsay
Journal:  Biochem Pharmacol       Date:  1979-08-01       Impact factor: 5.858

6.  Methimazole inhibits thyroid autoantibody production by an action on accessory cells.

Authors:  A P Weetman; A M McGregor; R Hall
Journal:  Clin Immunol Immunopathol       Date:  1983-07

7.  Carbimazole and the autoimmune response in Graves' disease.

Authors:  A M McGregor; M M Petersen; S M McLachlan; P Rooke; B R Smith; R Hall
Journal:  N Engl J Med       Date:  1980-08-07       Impact factor: 91.245

8.  Destruction of sympathetic nerve terminals by 6-hydroxydopamine: protection by 1-phenyl-3-(2-thiazolyl)-2-thiourea, diethyldithiocarbamate, methimazole, cysteamine, ethanol and n-butanol.

Authors:  G Cohen; R E Heikkila; B Allis; F Cabbat; D Dembiec; D MacNamee; C Mytilineou; B Winston
Journal:  J Pharmacol Exp Ther       Date:  1976-11       Impact factor: 4.030

9.  Chemiluminescence and superoxide production by myeloperoxidase-deficient leukocytes.

Authors:  H Rosen; S J Klebanoff
Journal:  J Clin Invest       Date:  1976-07       Impact factor: 14.808

10.  Rapid microassays for the measurement of superoxide and hydrogen peroxide production by macrophages in culture using an automatic enzyme immunoassay reader.

Authors:  E Pick; D Mizel
Journal:  J Immunol Methods       Date:  1981       Impact factor: 2.303
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  11 in total

Review 1.  [Endocrine orbit disorders. Pathogenesis, clinical presentation and examination, stage-dependent therapy].

Authors:  A Eckstein; J Esser
Journal:  Ophthalmologe       Date:  2003-10       Impact factor: 1.059

2.  Uptake and metabolism of iodine is crucial for the development of thyroiditis in obese strain chickens.

Authors:  T R Brown; R S Sundick; A Dhar; D Sheth; N Bagchi
Journal:  J Clin Invest       Date:  1991-07       Impact factor: 14.808

3.  Clinical applications of assays for thyrotropin-receptor antibodies in Graves' disease.

Authors:  J Ginsberg; C von Westarp
Journal:  CMAJ       Date:  1986-05-15       Impact factor: 8.262

4.  Thyroid follicular cell function after non-lethal complement membrane attack.

Authors:  A P Weetman; M Freeman; B P Morgan
Journal:  Clin Exp Immunol       Date:  1990-10       Impact factor: 4.330

5.  The effect of methimazole on the immune system is unlikely to operate directly on T lymphocytes.

Authors:  M Bagnasco; D Venuti; G Ciprandi; G Pesce; F Paolieri; G W Canonica
Journal:  J Endocrinol Invest       Date:  1990-06       Impact factor: 4.256

6.  The inhibitory effect of large doses of methimazole on iodine induced lymphocytic thyroiditis and serum anti-thyroglobulin antibody titers in BB/Wor rats.

Authors:  W Reinhardt; M C Appel; S Alex; Y N Yang; L E Braverman
Journal:  J Endocrinol Invest       Date:  1989-09       Impact factor: 4.256

7.  Effects of antioxidants on the blood-brain barrier and postischemic hyperemia.

Authors:  E Tasdemiroglu; P D Christenberry; J L Ardell; R B Chronister; A E Taylor
Journal:  Acta Neurochir (Wien)       Date:  1994       Impact factor: 2.216

8.  Inhibition of the receptor for interleukin-2 induced by carbimazole: relevance for the therapy of autoimmune thyroid disease.

Authors:  A Signore; P Pozzilli; U Di Mario; M Sensi; P Beales; D Andreani
Journal:  Clin Exp Immunol       Date:  1985-04       Impact factor: 4.330

9.  Thyroid stimulating immunoglobulin bioactivity during carbimazole therapy as measured by the cytochemical bioassay.

Authors:  M G Prentice; G A Rayman; J Alaghband-Zadeh; P H Wise
Journal:  J Endocrinol Invest       Date:  1987-10       Impact factor: 4.256

10.  Thyroxine, methimazole, and thyroid microsomal autoantibody titres in hypothyroid Hashimoto's thyroiditis.

Authors:  R Jansson; A Karlsson; P A Dahlberg
Journal:  Br Med J (Clin Res Ed)       Date:  1985-01-05
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