Literature DB >> 6687866

Molecular cloning of the rat metallothionein 1 (MT-1) mRNA sequence.

R D Andersen, B W Birren, T Ganz, J E Piletz, H R Herschman.   

Abstract

Starting with liver mRNA from cadmium chloride-treated rats, we constructed a cDNA library. A mouse metallothionein 1 (MT-1) cDNA restriction fragment (Durnam et al. 1980) was used as a hybridization probe to isolate from this library a cDNA (p2A10) which is a nearly complete copy of the rat MT-1 mRNA sequence. Southern analysis of rat DNA, using p2A10 as a probe, together with the screening of a rat genomic library, reveal that the rat MT-1 gene belongs to a family of related sequences. The rat MT-1 gene is inducible both by glucocorticoids and by metals.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6687866     DOI： 10.1089/dna.1.1983.2.15

Source DB:  PubMed          Journal:  DNA        ISSN： 0198-0238


  20 in total

1.  MPTP decreases MT-I mRNA in mouse striatum.

Authors:  P Rojas; J Rojas-Castañeda; R M Vigueras; S S Habeebu; C Rojas; C Ríos; M Ebadi
Journal:  Neurochem Res       Date:  2000-04       Impact factor: 3.996

2.  Nucleic acid composition, codon usage, and the rate of synonymous substitution in protein-coding genes.

Authors:  A Ticher; D Graur
Journal:  J Mol Evol       Date:  1989-04       Impact factor: 2.395

3.  Induction of hepatic metallothioneins determined at isoprotein and messenger RNA levels in glucocorticoid-treated rats.

Authors:  L D Lehman-McKeeman; G K Andrews; C D Klaassen
Journal:  Biochem J       Date:  1988-01-15       Impact factor: 3.857

4.  Assignment of genes encoding metallothioneins I and II to Chinese hamster chromosome 3: evidence for the role of chromosome rearrangement in gene amplification.

Authors:  R L Stallings; A C Munk; J L Longmire; C E Hildebrand; B D Crawford
Journal:  Mol Cell Biol       Date:  1984-12       Impact factor: 4.272

5.  Nonrandomness of point mutation as reflected in nucleotide substitutions in pseudogenes and its evolutionary implications.

Authors:  W H Li; C I Wu; C C Luo
Journal:  J Mol Evol       Date:  1984       Impact factor: 2.395

6.  Regulation of the rat metallothionein-I gene by sodium butyrate.

Authors:  B W Birren; H R Herschman
Journal:  Nucleic Acids Res       Date:  1986-01-24       Impact factor: 16.971

7.  Induction of metallothionein mRNA in rat liver and kidney after copper chloride injection.

Authors:  S A Wake; J F Mercer
Journal:  Biochem J       Date:  1985-06-01       Impact factor: 3.857

8.  Alternative inducers of the rat metallothionein I gene cause distinct changes in chromatin structure in the 5' region of the gene.

Authors:  S J Taplitz; K L Calame; H R Herschman
Journal:  Mol Cell Biol       Date:  1986-07       Impact factor: 4.272

9.  Metal-binding chimeric antibodies expressed in Escherichia coli.

Authors:  J R Sawyer; P W Tucker; F R Blattner
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-15       Impact factor: 11.205

10.  Novel revertants of H-ras oncogene-transformed R6-PKC3 cells.

Authors:  R S Krauss; S N Guadagno; I B Weinstein
Journal:  Mol Cell Biol       Date:  1992-07       Impact factor: 4.272
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.