Literature DB >> 6686587

Correlations between skin sensitization potential and chemical reactivity for p-nitrobenzyl compounds.

D W Roberts, B F Goodwin, D L Williams, K Jones, A W Johnson, J C Alderson.   

Abstract

Quantitative relationships between skin sensitization potential and certain physico-chemical properties of alkylating agents have been reported. This study demonstrates the correlation of the relative alkylation index (RAI), derived from the alkylation rate and lipophilicity of an alkylating agent, with a set of experimental sensitization data obtained for a series of p-nitrobenzyl compounds.

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Year:  1983        PMID： 6686587     DOI： 10.1016/0278-6915(83)90217-x

Source DB:  PubMed          Journal:  Food Chem Toxicol        ISSN： 0278-6915            Impact factor:   6.023


  3 in total

1.  Mechanistic understanding of molecular initiating events (MIEs) using NMR spectroscopy.

Authors:  Paul N Sanderson; Wendy Simpson; Richard Cubberley; Maja Aleksic; Stephen Gutsell; Paul J Russell
Journal:  Toxicol Res (Camb)       Date:  2015-09-15       Impact factor: 3.524

2.  Refinement of the relative alkylation index (RAI) model for skin sensitization and application to mouse and guinea-pig test data for alkyl alkanesulphonates.

Authors:  D W Roberts; R Fraginals; J P Lepoittevin; C Benezra
Journal:  Arch Dermatol Res       Date:  1991       Impact factor: 3.017

3.  Interpretation of murine local lymph node assay (LLNA) data for skin sensitization: Overload effects, danger signals and chemistry-based read-across.

Authors:  David W Roberts
Journal:  Curr Res Toxicol       Date:  2021-01-21
  3 in total

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