Literature DB >> 6686075

Evidence that 5-hydroxytryptamine in the forebrain is involved in naloxone-precipitated jumping in morphine-dependent rats.

L Cervo, S Romandini, R Samanin.   

Abstract

A withdrawal syndrome was precipitated by naloxone in morphine-dependent rats injected with 5,7-dihydroxytryptamine (5,7-DHT) in the ventromedial tegmentum (VMT) at the level of the nucleus interpeduncularis. 5,7-DHT, which markedly depleted 5-hydroxytryptamine (5-HT) in the forebrain but not in the brainstem, significantly reduced jumping in abstinent rats with no significant effect on other withdrawal signs. The effect of morphine 10 mg kg-1 on responses on the hot plate was unchanged in 5,7-DHT-treated rats. The findings suggest that 5-HT in the forebrain is selectively involved in the jumping of morphine-abstinent rats.

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Year:  1983        PMID： 6686075      PMCID： PMC2044952          DOI： 10.1111/j.1476-5381.1983.tb10546.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  13 in total

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Authors:  M Palkovits; J M Saavedra; D M Jacoboqitz; J S Kizer; L Záborszky; M J Brownstein
Journal:  Brain Res       Date:  1977-07-08       Impact factor: 3.252

2.  Neuroanatomical correlates of morphine dependence.

Authors:  E Wei; H H Loh; E L Way
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3.  Decreased antinociceptive activity of morphine in rats pretreated intraventricularly with 5,6-dihydroxytryptamine, a long-lasting selective depletor of brain serotonin.

Authors:  E Genovese; N Zonta; P Mantegazza
Journal:  Psychopharmacologia       Date:  1973-10-15

4.  A rapid and simple method for the determination of picogram levels of serotonin in brain tissue using liquid chromatography with electrochemical detection.

Authors:  F Ponzio; G Jonsson
Journal:  J Neurochem       Date:  1979-01       Impact factor: 5.372

5.  The effect of nomifensine on the depletion of brain serotonin and catecholamines induced respectively by fenfluramine and 6-hydroxydopamine in rats.

Authors:  R Samanin; S Bernasconi; S Garattini
Journal:  Eur J Pharmacol       Date:  1975-12       Impact factor: 4.432

6.  The effect of lowering the 5-hydroxytryptamine content of the rat spinal cord on analgesia produced by morphine.

Authors:  M Vogt
Journal:  J Physiol       Date:  1974-01       Impact factor: 5.182

7.  Effects of depletion of brain catecholamines during the development of morphine dependence on precipitated withdrawal in rats.

Authors:  J Bläsig; A Herz; C Gramsch
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1975       Impact factor: 3.000

8.  Morphine withdrawal syndrome: differential participation of structures located within the amygdaloid complex and striatum of the rat.

Authors:  B Calvino; J Lagowska; Y Ben-Ari
Journal:  Brain Res       Date:  1979-11-09       Impact factor: 3.252

9.  Evidence of a preferential role of brain serotonin in the mechanisms leading to naloxone-precipitated compulsive jumping in morphine-dependent rats.

Authors:  L Cervo; C Rochat; S Romandini; R Samanin
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

10.  Indoleamine antagonists: relative potencies as inhibitors of tryptamine- and 5-hydroxytryptophan-evoked responses.

Authors:  B V Clineschmidt; V J Lotti
Journal:  Br J Pharmacol       Date:  1974-02       Impact factor: 8.739
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  3 in total

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2.  Changes induced by sodium cromoglycate in brain catecholamine turnover in morphine dependent and abstinent mice.

Authors:  O San-Martín-Clark; B Cuéllar; J De Alba; J C Leza; P Lorenzo
Journal:  Psychopharmacology (Berl)       Date:  1995-04       Impact factor: 4.530

3.  Changes induced by sodium cromoglycate on brain serotonin turnover in morphine dependent and abstinent mice.

Authors:  O San-Martin-Clark; J C Leza; I Lizasoain; P Lorenzo
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530
  3 in total

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