| Literature DB >> 4558902 |
Abstract
Naloxone hydrochloride, an opioid antagonist, was applied to several discrete brain regions of morphine-dependent rats to precipitate abstinence. Severe withdrawal signs were elicited after administration in the thalamus but not in neocortical, hippocampal, hypothalamic, or tegmental areas of the brain.Entities:
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Year: 1972 PMID: 4558902 DOI: 10.1126/science.177.4049.616
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728