Literature DB >> 6684897

Treatment of intracranial dengue virus infections in mice with a lipophilic derivative of ribavirin.

W C Koff, R D Pratt, J L Elm, C N Venkateshan, S B Halstead.   

Abstract

Rimantadine, ribavirin, and 6-mercapto-9-(tetrahydro-2-furyl)purine, administered intraperitoneally every 8 h for 7 days starting minutes after virus challenge, had no effect on survival and mean survival time of BALB/c mice inoculated intracranially with dengue virus type 2. In contrast, intraperitoneal treatment with ribavirin 2',3',5'-triacetate, a lipophilic analog of ribavirin, effected significant increases in both mean survival time and survival rate, suggesting that ribavirin 2',3',5'-triacetate may be superior to rabavirin for treatment of viral diseases of the brain.

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Year:  1983        PMID： 6684897      PMCID： PMC185118          DOI： 10.1128/AAC.24.1.134

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  8 in total

1.  Aerosol therapy of influenza infections of mice and primates with rimantadine, ribavirin, and related compounds.

Authors:  E L Stephen; J S Walker; J W Dominik; H W Young; R F Berendt
Journal:  Ann N Y Acad Sci       Date:  1977-03-04       Impact factor: 5.691

2.  Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide.

Authors:  R W Sidwell; J H Huffman; G P Khare; L B Allen; J T Witkowski; R K Robins
Journal:  Science       Date:  1972-08-25       Impact factor: 47.728

3.  THE IN VIVO ANTIVIRAL ACTIVITY OF 1-ADAMANTANAMINE (AMANTADINE). I. PROPHYLACTIC AND THERAPEUTIC ACTIVITY AGAINST INFLUENZA VIRUSES.

Authors:  R R GRUNERT; J W MCGAHEN; W L DAVIES
Journal:  Virology       Date:  1965-06       Impact factor: 3.616

4.  Inhibition of bluetongue and Colorado tick fever orbiviruses by selected antiviral substances.

Authors:  D F Smee; R W Sidwell; S M Clark; B B Barnett; R S Spendlove
Journal:  Antimicrob Agents Chemother       Date:  1981-10       Impact factor: 5.191

5.  Suppression of dengue virus replication in vitro by rimantadine hydrochloride.

Authors:  W C Koff; J L Elm; S B Halstead
Journal:  Am J Trop Med Hyg       Date:  1981-01       Impact factor: 2.345

6.  Inhibition of dengue virus replication by amantadine hydrochloride.

Authors:  W C Koff; J L Elm; S B Halstead
Journal:  Antimicrob Agents Chemother       Date:  1980-07       Impact factor: 5.191

7.  Antiviral effects if ribavirin and 6-mercapto-9-tetrahydro-2-furylpurine against dengue viruses in vitro.

Authors:  W C Koff; J L Elm; S B Halstead
Journal:  Antiviral Res       Date:  1982-05       Impact factor: 5.970

8.  Observations related to the pathogenesis of dengue hemorrhagic fever. II. Antigenic and biologic properties of dengue viruses and their association with disease response in the host.

Authors:  S B Halstead; P Simasthien
Journal:  Yale J Biol Med       Date:  1970-04
  8 in total
  8 in total

Review 1.  Perspectives for the treatment of infections with Flaviviridae.

Authors:  P Leyssen; E De Clercq; J Neyts
Journal:  Clin Microbiol Rev       Date:  2000-01       Impact factor: 26.132

Review 2.  Biochemistry and clinical applications of ribavirin.

Authors:  B E Gilbert; V Knight
Journal:  Antimicrob Agents Chemother       Date:  1986-08       Impact factor: 5.191

3.  Identification of novel small-molecule inhibitors of West Nile virus infection.

Authors:  Amine O Noueiry; Paul D Olivo; Urszula Slomczynska; Yi Zhou; Ben Buscher; Brian Geiss; Michael Engle; Robert M Roth; Kyung Min Chung; Melanie Samuel; Michael S Diamond
Journal:  J Virol       Date:  2007-08-22       Impact factor: 5.103

4.  Failure of interferon alfa and tribavirin in rabies encephalitis.

Authors:  M J Warrell; N J White; S Looareesuwan; R E Phillips; P Suntharasamai; P Chanthavanich; M Riganti; S P Fisher-Hoch; K G Nicholson; S Manatsathit
Journal:  BMJ       Date:  1989-09-30

5.  Aerosol and intraperitoneal administration of ribavirin and ribavirin triacetate: pharmacokinetics and protection of mice against intracerebral infection with influenza A/WSN virus.

Authors:  B E Gilbert; P R Wyde; S Z Wilson; R K Robins
Journal:  Antimicrob Agents Chemother       Date:  1991-07       Impact factor: 5.191

6.  Structure-based and ligand-based virtual screening of novel methyltransferase inhibitors of the dengue virus.

Authors:  See Ven Lim; Mohd Basyaruddin A Rahman; Bimo A Tejo
Journal:  BMC Bioinformatics       Date:  2011-11-30       Impact factor: 3.169

Review 7.  Understanding the dengue viruses and progress towards their control.

Authors:  Rosmari Rodriguez-Roche; Ernest A Gould
Journal:  Biomed Res Int       Date:  2013-07-09       Impact factor: 3.411

8.  Chapter 12. Antiviral Agents.

Authors:  James L Kelley
Journal:  Annu Rep Med Chem       Date:  2008-04-10       Impact factor: 1.059
  8 in total

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