Literature DB >> 6684057

Effect of islet-activating protein (IAP) on contractile responses of rat vas deferens: evidence for participation of Ni (inhibitory GTP binding regulating protein) in the alpha 2-adrenoceptor-mediated response.

R T Lai, Y Watanabe, H Yoshida.   

Abstract

The effects of islet-activating protein (IAP) on the contractile responses of vas deferens to exogenous norepinephrine (NE) and electric stimulation (ES) were investigated. IAP treatment had no effect on the contractile response to NE. Pretreatment of the vas deferens with IAP (2.0 micrograms/ml) for 2 h however significantly attenuated the inhibitory effect of clonidine on ES-induced contractile responses, suggesting that feedback inhibition of presynaptic alpha 2-adrenoceptors is mediated by the Ni subunit of presynaptic adenylate cyclase.

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Year:  1983        PMID： 6684057     DOI： 10.1016/0014-2999(83)90572-1

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

1.  Pertussis toxin abolishes the inhibition of Ca2+ currents and of noradrenaline release via alpha 2-adrenoceptors in chick sympathetic neurons.

Authors:  S Boehm; S Huck; H Drobny; E A Singer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-05       Impact factor: 3.000

2.  One hundred years of adrenaline: the discovery of autoreceptors.

Authors:  M R Bennett
Journal:  Clin Auton Res       Date:  1999-06       Impact factor: 4.435

3.  Islet-activating protein (pertussis toxin) diminishes alpha 2-adrenoceptor mediated effects on noradrenaline release.

Authors:  C Allgaier; T J Feuerstein; R Jackisch; G Hertting
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-11       Impact factor: 3.000

4.  N-ethylmaleimide (NEM) diminishes alpha 2-adrenoceptor mediated effects on noradrenaline release.

Authors:  C Allgaier; T J Feuerstein; G Hertting
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-06       Impact factor: 3.000

5.  Participation of protein kinase C and regulatory G proteins in modulation of the evoked noradrenaline release in brain.

Authors:  G Hertting; C Allgaier
Journal:  Cell Mol Neurobiol       Date:  1988-03       Impact factor: 5.046

6.  Prejunctional alpha 2-adrenoceptors in mouse atria function through G-proteins which are sensitive to N-ethylmaleimide, but not pertussis toxin.

Authors:  T V Murphy; S Foucart; H Majewski
Journal:  Br J Pharmacol       Date:  1992-08       Impact factor: 8.739

7.  Field stimulation-induced noradrenaline release from guinea-pig atria is modulated by prejunctional alpha 2-adrenoceptors and protein kinase C.

Authors:  H Brasch
Journal:  Basic Res Cardiol       Date:  1993 Nov-Dec       Impact factor: 17.165

8.  Pertussis toxin does not attenuate alpha 2-adrenoceptor mediated inhibition of noradrenaline release in mouse atria.

Authors:  I Musgrave; P Marley; H Majewski
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-09       Impact factor: 3.000
  8 in total

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