Literature DB >> 6684000

Oral levonantradol in the control of cancer chemotherapy-induced emesis.

J Welsh, F Stuart, G Sangster, R Milstead, S Kaye, H Cash, D Charlton, K Calman.   

Abstract

A dose-ranging study with oral levonantradol was performed in 20 cancer patients. The optimum oral dose which attenuated vomiting accompanying chemotherapy was 1 mg 4-hourly. Side-effects comprised dizziness, confusion, euphoria, drowsiness, and difficulty in concentrating. There was no cardiovascular toxicity. Overall toxicity appeared to be dose-related and was mild and acceptable.

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Year:  1983        PMID: 6684000     DOI: 10.1007/bf00257422

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN: 0344-5704            Impact factor:   3.333


  11 in total

1.  Letter: Cancer treatment needs better antiemetics.

Authors:  V M Whitehead
Journal:  N Engl J Med       Date:  1975-07-24       Impact factor: 91.245

2.  A CONTROLLED CLINICAL EVALUATION OF ANTIEMETIC DRUGS.

Authors:  C G MOERTEL; R J REITEMEIER; R P GAGE
Journal:  JAMA       Date:  1963-10-12       Impact factor: 56.272

3.  Controlled clinical studies of orally administered antiemetic drugs.

Authors:  C G Moertel; R J Reitemeier
Journal:  Gastroenterology       Date:  1969-09       Impact factor: 22.682

4.  Cytotoxic-therapy-induced vomiting is mediated via enkephalin pathways.

Authors:  A L Harris
Journal:  Lancet       Date:  1982-03-27       Impact factor: 79.321

5.  Antiemetics: neurotransmitter receptor binding predicts therapeutic actions.

Authors:  S J Peroutka; S H Snyder
Journal:  Lancet       Date:  1982-03-20       Impact factor: 79.321

6.  Antiemetic effect of delta-9-tetrahydrocannabinol in patients receiving cancer chemotherapy.

Authors:  S E Sallan; N E Zinberg; E Frei
Journal:  N Engl J Med       Date:  1975-10-16       Impact factor: 91.245

7.  A comparison of the antiemetic effects of droperidol and prochlorperazine in chemotheray with cis-platinum.

Authors:  A J Jacobs; G Deppe; C J Cohen
Journal:  Gynecol Oncol       Date:  1980-08       Impact factor: 5.482

8.  Antiemetic efficacy of high-dose metoclopramide: randomized trials with placebo and prochlorperazine in patients with chemotherapy-induced nausea and vomiting.

Authors:  R J Gralla; L M Itri; S E Pisko; A E Squillante; D P Kelsen; D W Braun; L A Bordin; T J Braun; C W Young
Journal:  N Engl J Med       Date:  1981-10-15       Impact factor: 91.245

9.  Toxicity of cis-diamminedichloroplatinum II given in a two-hour outpatient regimen of diuresis and hydration.

Authors:  S E Vogl; T Zaravinos; B H Kaplan
Journal:  Cancer       Date:  1980-01-01       Impact factor: 6.860

10.  Delta-9-tetrahydrocannabinol as an antiemetic for patients receiving cancer chemotherapy. A comparison with prochlorperazine and a placebo.

Authors:  S Frytak; C G Moertel; J R O'Fallon; J Rubin; E T Creagan; M J O'Connell; A J Schutt; N W Schwartau
Journal:  Ann Intern Med       Date:  1979-12       Impact factor: 25.391

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