Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Interaction of diamidino-2-phenylindole (DAPI) with natural and synthetic nucleic acids.

Literature DB >> 6672773

Interaction of diamidino-2-phenylindole (DAPI) with natural and synthetic nucleic acids.

G Manzini, M L Barcellona, M Avitabile, F Quadrifoglio.

Abstract

The interaction of DAPI with natural and synthetic polydeoxynucleotides of different base content and sequences was studied with circular dichroism, ultracentrifugation, viscosity and calorimetry. All the polymers show two types of binding. The strength of the interaction and its resistance to ionic strength are related to the content of AT clusters in the chain. On the other hand, sedimentation measurements rule out an intercalation mechanism. A model of DAPI interaction with DNA, similar to that displayed by distamycin and netropsin, is proposed.

Entities: Chemical

Mesh：

Substances：

Year: 1983 PMID： 6672773 PMCID： PMC326630 DOI： 10.1093/nar/11.24.8861

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

29 in total

1. The use of fluorescent DNA-binding agent for detecting and separating yeast mitochondrial DNA.

Authors: D H Williamson; D J Fennell
Journal: Methods Cell Biol Date: 1975 Impact factor: 1.441

2. Demonstration of kinetoplast DNA in dyskinetoplastic strains of Trypanosoma equiperdum.

Authors: S L Hajduk
Journal: Science Date: 1976-02-27 Impact factor: 47.728

3. Netropsin. A specific probe for A-T regions of duplex deoxyribonucleic acid.

Authors: R M Wartell; J E Larson; R D Wells
Journal: J Biol Chem Date: 1974-11-10 Impact factor: 5.157

4. Adenosine-thymidine cluster-specific elongation and stiffening of DNA induced by the oligopeptide antibiotic netropsin.

Authors: K E Reinert
Journal: J Mol Biol Date: 1972-12-30 Impact factor: 5.469

5. Interaction of the oligopeptide antibiotics netropsin and distamycin A with nucleic acids.

Authors: C Zimmer; K E Reinert; G Luck; U Wähnert; G Löber; H Thrum
Journal: J Mol Biol Date: 1971-05-28 Impact factor: 5.469

6. Variation of the supercoils in closed circular DNA by binding of antibiotics and drugs: evidence for molecular models involving intercalation.

Authors: M Waring
Journal: J Mol Biol Date: 1970-12-14 Impact factor: 5.469

7. A simple cytochemical technique for demonstration of DNA in cells infected with mycoplasmas and viruses.

Authors: W C Russell; C Newman; D H Williamson
Journal: Nature Date: 1975-02-06 Impact factor: 49.962

8. Heterochromatin diversity in Cymbidium, and its relationship to differential DNA replication.

Authors: D Schweizer; W Nagl
Journal: Exp Cell Res Date: 1976-03-15 Impact factor: 3.905

9. Conformation dependent binding of netropsin and distamycin to DNA and DNA model polymers.

Authors: G Luck; H Triebel; M Waring; C Zimmer
Journal: Nucleic Acids Res Date: 1974-03 Impact factor: 16.971

10. Use of a sequence-specific DNA-binding ligand to probe the environments of EcoRI restriction endonuclease cleavage sites.

Authors: J Kania; T G Fanning
Journal: Eur J Biochem Date: 1976-08-16

26 in total

1. Dermal fibroblasts participate in the formation of new muscle fibres when implanted into regenerating normal mouse muscle.

Authors: D Pye; D J Watt
Journal: J Anat Date: 2001-02 Impact factor: 2.610

2. Binding of Cu(II) complexes of oxicam NSAIDs to alternating AT and homopolymeric AT sequences: differential response to variation in backbone structure.

Authors: Sreeja Chakraborty; Esha Sehanobish; Munna Sarkar
Journal: J Biol Inorg Chem Date: 2012-01-20 Impact factor: 3.358

3. Nuclear DNA content in the genus Hepatica (Ranunculaceae).

Authors: Tomoo Mabuchi; Hisashi Kokubun; Masahiro Mii; Toshio Ando
Journal: J Plant Res Date: 2005-02-15 Impact factor: 2.629

4. The hazards of DAPI photoconversion: effects of dye, mounting media and fixative, and how to minimize the problem.

Authors: Mojca Jež; Tuba Bas; Matija Veber; Andrej Košir; Tanja Dominko; Raymond Page; Primož Rožman
Journal: Histochem Cell Biol Date: 2012-10-14 Impact factor: 4.304

5. Fluorescence anisotropy of DNA/DAPI complex: torsional dynamics and geometry of the complex.

Authors: M L Barcellona; E Gratton
Journal: Biophys J Date: 1996-05 Impact factor: 4.033

6. Evidence for DAPI intercalation in CG sites of DNA oligomer [d(CGACGTCG)]2: a 1H NMR study.

Authors: E Trotta; E D'Ambrosio; G Ravagnan; M Paci
Journal: Nucleic Acids Res Date: 1995-04-25 Impact factor: 16.971

7. Structure-activity relationships of pentamidine analogs against Giardia lamblia and correlation of antigiardial activity with DNA-binding affinity.

Authors: C A Bell; M Cory; T A Fairley; J E Hall; R R Tidwell
Journal: Antimicrob Agents Chemother Date: 1991-06 Impact factor: 5.191