Literature DB >> 6672767

The effect of adriamycin on Z-DNA formation and DNA synthesis.

P D Van Helden.   

Abstract

The ability of adriamycin to inhibit Z-DNA formation induced by a high-salt environment was investigated. ADM inhibited this conversion, such that in poly (dG-dC) total inhibition was observed at 1 ADM: 9 base pairs and in eukaryotic DNA (calf thymus) at 1 ADM: 11,5 base pairs. Even at low ADM concentration, 1 ADM: 160 base pairs, some inhibition was observed. At similar ADM:DNA concentrations, an inhibition in DNA synthesis in cells in culture was observed, which showed some parallel with the inhibition of Z-DNA formation. A model is proposed where Z-DNA formation precedes DNA synthesis and where inhibition of the former could explain the antineoplastic nature of adriamycin.

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Year:  1983        PMID： 6672767      PMCID： PMC326591          DOI： 10.1093/nar/11.23.8415

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  13 in total

1.  Stretches of alternating poly(T-dG), with the capacity to form Z-DNA, are present in human liver transcripts.

Authors:  C Santoro; F Costanzo
Journal:  FEBS Lett       Date:  1983-05-02       Impact factor: 4.124

2.  New twists to left-handed DNA.

Authors:  S Neidle
Journal:  Nature       Date:  1983-04-14       Impact factor: 49.962

3.  A better cell line for making hybridomas secreting specific antibodies.

Authors:  M Shulman; C D Wilde; G Köhler
Journal:  Nature       Date:  1978-11-16       Impact factor: 49.962

4.  Predicted mode of intercalation of doxorubicin with dinucleotide dimers.

Authors:  Y Nakata; A J Hopfinger
Journal:  Biochem Biophys Res Commun       Date:  1980-07-31       Impact factor: 3.575

5.  Antibodies to left-handed Z-DNA bind to interband regions of Drosophila polytene chromosomes.

Authors:  A Nordheim; M L Pardue; E M Lafer; A Möller; B D Stollar; A Rich
Journal:  Nature       Date:  1981-12-03       Impact factor: 49.962

6.  Effects of adriamycin on heart and skeletal muscle chromatin.

Authors:  P D Van Helden; I J Wild
Journal:  Biochem Pharmacol       Date:  1982-03-15       Impact factor: 5.858

7.  Differential effect of adriamycin on DNA replicative and repair synthesis in cultured neonatal rat cardiac cells.

Authors:  H Fialkoff; M F Goodman; M W Seraydarian
Journal:  Cancer Res       Date:  1979-04       Impact factor: 12.701

8.  Effect of adriamycin on the polyribosome and messenger-RNA content of rat heart muscle.

Authors:  J Zähringer; B Höfling; W Raum; R Kandolph
Journal:  Biochim Biophys Acta       Date:  1980-07-29

9.  The effect of intercalating drugs on the kinetics of the B to Z transition of poly(dG-dC).

Authors:  P A Mirau; D R Kearns
Journal:  Nucleic Acids Res       Date:  1983-03-25       Impact factor: 16.971

10.  Facile transition of poly[d(TG) x d(CA)] into a left-handed helix in physiological conditions.

Authors:  D B Haniford; D E Pulleyblank
Journal:  Nature       Date:  1983-04-14       Impact factor: 49.962
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  4 in total

1.  Inhibition of transcription by adriamycin is a consequence of the loss of negative superhelicity in DNA mediated by topoisomerase II.

Authors:  M Tarr; P D van Helden
Journal:  Mol Cell Biochem       Date:  1990-03-27       Impact factor: 3.396

2.  Circular dichroism of poly(dG-dC) modified by the carcinogens N-methyl-4-aminoazobenzene or 4-aminobiphenyl.

Authors:  P A Abuaf; F F Kadlubar; D Grunberger
Journal:  Nucleic Acids Res       Date:  1987-09-11       Impact factor: 16.971

3.  A new assay for anti-DNA antibodies in serum which includes the measurement of anti-Z-DNA.

Authors:  P D Van Helden; L Van Lill; A J Bester; L De Waal; E G Hoal-van Helden
Journal:  Clin Exp Immunol       Date:  1987-08       Impact factor: 4.330

4.  Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction.

Authors:  Paul R Marshall; Qiongyi Zhao; Xiang Li; Wei Wei; Ambika Periyakaruppiah; Esmi L Zajaczkowski; Laura J Leighton; Sachithrani U Madugalle; Dean Basic; Ziqi Wang; Jiayu Yin; Wei-Siang Liau; Ankita Gupte; Carl R Walkley; Timothy W Bredy
Journal:  Nat Neurosci       Date:  2020-05-04       Impact factor: 24.884
  4 in total

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