| Literature DB >> 6156705 |
J Zähringer, B Höfling, W Raum, R Kandolph.
Abstract
The myocardial contents of DNA, protein, total and polyribosomal RNA, messenger RNA (mRNA) and polyribosomes were determined in normal and adriamycin-treated rats. While the myocardial contents of DNA and protein changed only little in adriamycin-treated rats, total and polyribosomal RNA decreased by 23.2% and 35%, mRNA and polyribosomes by 51.6% and 38.7%. Size distribution and protein synthetic activity of the polyribosome preparations obtained remained unchanged in the adriamycin-treated rats. We conclude that the reduced myocardial contents of RNA, mRNA and polyribosomes cause the previously observed impairment of myocardial protein synthesis in adriamycin-treated rats and might be important in the pathogenesis of the adriamycin-cardiomyopathy.Entities:
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Year: 1980 PMID： 6156705 DOI： 10.1016/0005-2787(80)90177-x
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002