Literature DB >> 6668072

Pharmacokinetic properties of the new cephalosporin antibiotic HR 810 in animals.

N Klesel, K Seeger.   

Abstract

The pharmacokinetic profile of HR 810 was investigated in mice, rats, rabbits, dogs and monkeys. High blood resp. serum levels were achieved following subcutaneous, intramuscular and intravenous injection, and half-lives ranged from 20 min in mice to 89 min in rabbits. The compound was well distributed in the body and penetrated tissues and body fluids to a high degree. While large amounts of the antibiotic were recovered in the animals' urine, the recovery rate in bile was very low. These good pharmacokinetic properties, together with its high antibacterial activity, open the way for the evaluation of HR 810 in humans.

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Year:  1983        PMID： 6668072     DOI： 10.1007/bf01641356

Source DB:  PubMed          Journal:  Infection        ISSN： 0300-8126            Impact factor:   3.553


  3 in total

1.  Therapeutic and kinetic properties of ceftazidime in animals.

Authors:  P Acred
Journal:  Infection       Date:  1983       Impact factor: 3.553

2.  HR 810, a new parenteral cephalosporin with a broad antibacterial spectrum.

Authors:  G Seibert; N Klesel; M Limbert; E Schrinner; K Seeger; I Winkler; R Lattrell; J Blumbach; W Dürckheimer; K Fleischmann
Journal:  Arzneimittelforschung       Date:  1983

3.  The Antibacterial activity in vitro and beta-lactamase stability of the new cephalosporin HR 810 in comparison with five other cephalosporins and two aminoglycosides.

Authors:  G Seibert; M Limbert; I Winkler; T Dick
Journal:  Infection       Date:  1983 Sep-Oct       Impact factor: 3.553
  3 in total
  7 in total

1.  Pharmacokinetics of cefpirome (HR 810), a new cephalosporin derivative administered intramuscularly and intravenously to healthy volunteers.

Authors:  L Maass; V Malerczyk; M Verho
Journal:  Infection       Date:  1987 May-Jun       Impact factor: 3.553

2.  Distribution of cefpirome (HR 810) to exudate in the croton oil-induced rat granuloma pouch and its therapeutic effects on experimental infections in the pouch.

Authors:  S Arai; S Kobayashi; S Hayashi; T Sakaguchi
Journal:  Antimicrob Agents Chemother       Date:  1988-09       Impact factor: 5.191

3.  High-pressure liquid chromatographic assay and pharmacokinetics of HR 810 after intramuscular injection in rabbits.

Authors:  R E Bawdon; Y S Lu; D C Brater
Journal:  Antimicrob Agents Chemother       Date:  1985-04       Impact factor: 5.191

4.  Disposition kinetics and urinary excretion of cefpirome after intravenous injection in buffalo calves.

Authors:  Neetu Rajput; Vinod K Dumka; Harpal S Sandhu
Journal:  J Vet Sci       Date:  2007-03       Impact factor: 1.672

5.  Relative efficacies of broad-spectrum cephalosporins for treatment of methicillin-susceptible Staphylococcus aureus experimental infective endocarditis.

Authors:  J M Steckelberg; M S Rouse; B M Tallan; D R Osmon; N K Henry; W R Wilson
Journal:  Antimicrob Agents Chemother       Date:  1993-03       Impact factor: 5.191

6.  Chemotherapeutic properties of the new cephalosporin antibiotic HR810 in laboratory animals.

Authors:  N Klesel; M Limbert; E Schrinner; K Seeger; G Seibert; I Winkler
Journal:  Infection       Date:  1984 Jul-Aug       Impact factor: 3.553

7.  Pharmacokinetics of the novel cephalosporin cefepime (BMY-28142) in rats and monkeys.

Authors:  S T Forgue; W C Shyu; C R Gleason; K A Pittman; R H Barbhaiya
Journal:  Antimicrob Agents Chemother       Date:  1987-05       Impact factor: 5.191
  7 in total

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