Literature DB >> 6664615

Identification of quinolinic acid in rat and human brain tissue.

M Wolfensberger, U Amsler, M Cuénod, A C Foster, W O Whetsell, R Schwarcz.   

Abstract

An analytical technique for the determination of the excitotoxic compound quinolinic acid (2,3-pyridine dicarboxylic acid) in brain tissue has been developed. Following sample prepurification by ion exchange and high pressure liquid chromatography, quinolinic acid is converted to the dihexafluoroisopropyl ester and the derivative is analyzed by mass fragmentography. Using the present technique quinolinic acid has been identified in both rat and human brain tissue.

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Year:  1983        PMID： 6664615     DOI： 10.1016/0304-3940(83)90458-5

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  28 in total

1.  Bioanalytical inaccuracy: a threat to the integrity and efficiency of research.

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Review 2.  Release of neuroactive substances: homocysteic acid as an endogenous agonist of the NMDA receptor.

Authors:  K Q Do; P L Herrling; P Streit; M Cuénod
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3.  3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims.

Authors:  R Schwarcz; E Okuno; R J White; E D Bird; W O Whetsell
Journal:  Proc Natl Acad Sci U S A       Date:  1988-06       Impact factor: 11.205

4.  Increase of adenine nucleotide hydrolysis in rat hippocampal slices after seizures induced by quinolinic acid.

Authors:  Rafael Nicolaidis; Alessandra Nejar Bruno; João José Freitas Sarkis; Diogo Onofre Souza
Journal:  Neurochem Res       Date:  2005-03       Impact factor: 3.996

5.  Quinolinic acid phosphoribosyltransferase: preferential glial localization in the rat brain visualized by immunocytochemistry.

Authors:  C Köhler; E Okuno; P R Flood; R Schwarcz
Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205

6.  Influence of Iron Deficiency on Olfactory Behavior in Weanling Rats.

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7.  Excitatory amino acids as modulators of gonadotropin secretion.

Authors:  M Zanisi; E Messi; M Galbiati
Journal:  Amino Acids       Date:  1994-02       Impact factor: 3.520

8.  Nitric oxide synthase inhibition prevents acute quinolinate-induced striatal neurotoxicity.

Authors:  F Pérez-Severiano; B Escalante; C Ríos
Journal:  Neurochem Res       Date:  1998-10       Impact factor: 3.996

Review 9.  Cerebrospinal fluid (CSF) analyses in HIV-1 primary neurological disease.

Authors:  J Nogales-Gaete; K Syndulko; W W Tourtellotte
Journal:  Ital J Neurol Sci       Date:  1992-11

Review 10.  Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease.

Authors:  Robert Schwarcz; Paolo Guidetti; Korrapati V Sathyasaikumar; Paul J Muchowski
Journal:  Prog Neurobiol       Date:  2009-04-24       Impact factor: 11.685
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