Literature DB >> 2901456

Release of neuroactive substances: homocysteic acid as an endogenous agonist of the NMDA receptor.

K Q Do1, P L Herrling, P Streit, M Cuénod.   

Abstract

Sulfur containing amino acids such as homocysteic acid (HCA), cysteinsulfinic acid, homocysteinsulfinic acid are released by depolarization of slices from various rat brain regions in a Ca++-dependent manner. L-HCA excites caudate neurons through their N-methyl-D-aspartic acid (NMDA) receptor and potentiates their cortically evoked excitatory postsynaptic potentials. 35S-methionine can label the releasable pool of HCA, and thus appears as a precursor of HCA. Thus HCA is a transmitter candidate which acts predominantly on the NMDA receptor.

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Year:  1988        PMID： 2901456     DOI： 10.1007/bf01243418

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  25 in total

1.  Actions of L- and D-homocysteate in rat CNS: a correlation between low-affinity uptake and the time courses of excitation by microelectrophoretically applied L-glutamate analogues.

Authors:  D W Cox; M H Headley; J C Watkins
Journal:  J Neurochem       Date:  1977-09       Impact factor: 5.372

Review 2.  Excitatory amino acid transmitters.

Authors:  J C Watkins; R H Evans
Journal:  Annu Rev Pharmacol Toxicol       Date:  1981       Impact factor: 13.820

Review 3.  Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters.

Authors:  B Meldrum
Journal:  Clin Sci (Lond)       Date:  1985-02       Impact factor: 6.124

4.  Homocysteic acid, an endogenous agonist of NMDA-receptor: release, neuroactivity and localization.

Authors:  M Cuénod; K Q Do; P L Herrling; W A Turski; C Matute; P Streit
Journal:  Adv Exp Med Biol       Date:  1986       Impact factor: 2.622

5.  Excitotoxic models for neurodegenerative disorders.

Authors:  R Schwarcz; A C Foster; E D French; W O Whetsell; C Köhler
Journal:  Life Sci       Date:  1984-07-02       Impact factor: 5.037

6.  Cysteine sulfinic acid in the central nervous system: uptake and release of cysteine sulfinic acid by a rat brain preparation.

Authors:  H Iwata; S Yamagami; H Mizuo; A Baba
Journal:  J Neurochem       Date:  1982-05       Impact factor: 5.372

7.  Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain.

Authors:  R Schwarcz; W O Whetsell; R M Mangano
Journal:  Science       Date:  1983-01-21       Impact factor: 47.728

8.  Effects of excitatory amino acids and their antagonists on membrane and action potentials of cat caudate neurones.

Authors:  P L Herrling; R Morris; T E Salt
Journal:  J Physiol       Date:  1983-06       Impact factor: 5.182

9.  Pharmacology of the excitatory actions of sulphonic and sulphinic amino acids.

Authors:  K N Mewett; D J Oakes; H J Olverman; D A Smith; J C Watkins
Journal:  Adv Biochem Psychopharmacol       Date:  1983

10.  Isomers of 2-amino-7-phosphonoheptanoic acid as antagonists of neuronal excitants.

Authors:  M N Perkins; J F Collins; T W Stone
Journal:  Neurosci Lett       Date:  1982-09-20       Impact factor: 3.046
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  14 in total

Review 1.  The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities.

Authors:  Jan Lewerenz; Sandra J Hewett; Ying Huang; Maria Lambros; Peter W Gout; Peter W Kalivas; Ann Massie; Ilse Smolders; Axel Methner; Mathias Pergande; Sylvia B Smith; Vadivel Ganapathy; Pamela Maher
Journal:  Antioxid Redox Signal       Date:  2012-08-03       Impact factor: 8.401

2.  Differential cellular distribution of two sulphur-containing amino acids in rat cerebellum. An immunocytochemical investigation using antisera to taurine and homocysteic acid.

Authors:  N Zhang; O P Ottersen
Journal:  Exp Brain Res       Date:  1992       Impact factor: 1.972

Review 3.  Glutamate receptor ion channels: structure, regulation, and function.

Authors:  Stephen F Traynelis; Lonnie P Wollmuth; Chris J McBain; Frank S Menniti; Katie M Vance; Kevin K Ogden; Kasper B Hansen; Hongjie Yuan; Scott J Myers; Ray Dingledine
Journal:  Pharmacol Rev       Date:  2010-09       Impact factor: 25.468

4.  Excitatory sulphur amino acid-evoked neurotransmitter release from rat brain synaptosome fractions.

Authors:  J Dunlop; H Mason; A Grieve; R Griffiths
Journal:  J Neural Transm Gen Sect       Date:  1989

5.  Steroid-induced alterations of mood and behavior in children during treatment for acute lymphoblastic leukemia.

Authors:  Carl J Hochhauser; Michael Lewis; Barton A Kamen; Peter D Cole
Journal:  Support Care Cancer       Date:  2005-09-28       Impact factor: 3.603

6.  Retinal Ganglion Cell Loss and Mild Vasculopathy in Methylene Tetrahydrofolate Reductase (Mthfr)-Deficient Mice: A Model of Mild Hyperhomocysteinemia.

Authors:  Shanu Markand; Alan Saul; Penny Roon; Puttur Prasad; Pamela Martin; Rima Rozen; Vadivel Ganapathy; Sylvia B Smith
Journal:  Invest Ophthalmol Vis Sci       Date:  2015-04       Impact factor: 4.799

7.  Endogenous elevation of homocysteine induces retinal neuron death in the cystathionine-beta-synthase mutant mouse.

Authors:  Preethi S Ganapathy; Brent Moister; Penny Roon; Barbara A Mysona; Jennifer Duplantier; Ying Dun; Tracy K V E Moister; Marlena J Farley; Puttur D Prasad; Kebin Liu; Sylvia B Smith
Journal:  Invest Ophthalmol Vis Sci       Date:  2009-04-08       Impact factor: 4.799

Review 8.  Main path and byways: non-vesicular glutamate release by system xc(-) as an important modifier of glutamatergic neurotransmission.

Authors:  Ann Massie; Séverine Boillée; Sandra Hewett; Lori Knackstedt; Jan Lewerenz
Journal:  J Neurochem       Date:  2015-09-29       Impact factor: 5.372

9.  Effects of ageing on the content in sulfur-containing amino acids in rat brain.

Authors:  M S Benedetti; A Russo; P Marrari; P Dostert
Journal:  J Neural Transm Gen Sect       Date:  1991

10.  Treatment of Alzheimer's disease with anti-homocysteic acid antibody in 3xTg-AD male mice.

Authors:  Tohru Hasegawa; Nobuyuki Mikoda; Masashi Kitazawa; Frank M LaFerla
Journal:  PLoS One       Date:  2010-01-20       Impact factor: 3.240
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