Literature DB >> 6661213

The stimulation of glycogenolysis and gluconeogenesis in isolated hepatocytes by opioid peptides.

E H Allan, I C Green, M A Titheradge.   

Abstract

The opioid agonists [leucine]enkephalin, [D-Ala2,D-Leu5]enkephalin and dynorphin-(1-13)-peptide, but not morphine, stimulated the conversion of [2-14C]pyruvate into glucose and glycogenolysis when added directly to isolated hepatocytes. Naloxone produced a small but significant inhibition of both the basal and stimulated rate of incorporation of label into glucose but had no effect on the total glucose output by the cells. The effects of the opioid peptides were mediated by a cyclic AMP-independent mechanism.

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Year:  1983        PMID： 6661213      PMCID： PMC1152532          DOI： 10.1042/bj2160507

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  14 in total

1.  Evidence for morphine and morphine-like alkaloid responses resistant to naloxone blockade in the rat vas deferens.

Authors:  H Miranda; F Huidobro; J P Huidobro-Toro
Journal:  Life Sci       Date:  1979-04-16       Impact factor: 5.037

2.  Morphine and beta-endorphin influence the secretion of the endocrine pancreas.

Authors:  E Ipp; R Dobbs; R H Unger
Journal:  Nature       Date:  1978-11-09       Impact factor: 49.962

3.  Hyperglycaemia produced by drugs with analgesic properties introduced into the cerebral ventricles of cats.

Authors:  P K Dey; W Feldberg
Journal:  Br J Pharmacol       Date:  1975-06       Impact factor: 8.739

4.  Effects of morphine on isoenzymes of pyruvate kinase and tyrosine aminotransferase in rat.

Authors:  S C Wong; Y G Yeung; D Yeung
Journal:  Biochem Pharmacol       Date:  1978-05-01       Impact factor: 5.858

5.  Effect of morphine on gluconeogenesis and ureogenesis in rat liver.

Authors:  S C Wong; D C Yeung
Journal:  Int J Biochem       Date:  1981

6.  Regional distribution of a high-affinity enkephalin-degrading peptidase ('enkephalinase') and effects of lesions suggest localization in the vicinity of opiate receptors in brain.

Authors:  B Malfroy; J P Swerts; C Llorens; J C Schwartz
Journal:  Neurosci Lett       Date:  1979-03       Impact factor: 3.046

7.  Endogenous opioid peptides: multiple agonists and receptors.

Authors:  J A Lord; A A Waterfield; J Hughes; H W Kosterlitz
Journal:  Nature       Date:  1977-06-09       Impact factor: 49.962

8.  beta-Endorphin stimulates the secretion of insulin and glucagon in humans.

Authors:  R L Reid; S S Yen
Journal:  J Clin Endocrinol Metab       Date:  1981-03       Impact factor: 5.958

9.  Morphine hyperglycaemia.

Authors:  W Feldberg; K P Gupta
Journal:  J Physiol       Date:  1974-05       Impact factor: 5.182

10.  Effect of enkephalins and morphine on insulin secretion from isolated rat islets.

Authors:  I C Green; D Perrin; K C Pedley; R D Leslie; D A Pyke
Journal:  Diabetologia       Date:  1980-08       Impact factor: 10.122
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  12 in total

Review 1.  Opioid peptides and glucose metabolism.

Authors:  A Lala; P Bouloux; G Tamburrano; E Gale
Journal:  J Endocrinol Invest       Date:  1987-02       Impact factor: 4.256

Review 2.  Opioid peptides and metabolic regulation.

Authors:  D Giugliano; R Torella; P J Lefèbvre; F D'Onofrio
Journal:  Diabetologia       Date:  1988-01       Impact factor: 10.122

3.  Comparison of the effects of [leucine]enkephalin and angiotensin on hepatic carbohydrate and cyclic nucleotide metabolism.

Authors:  S K Hothi; R P Leach; M A Titheradge
Journal:  Biochem J       Date:  1988-02-01       Impact factor: 3.857

4.  The stimulation of glycogenolysis in isolated hepatocytes by opioid peptides.

Authors:  R P Leach; M A Titheradge
Journal:  Biochem J       Date:  1986-09-01       Impact factor: 3.857

Review 5.  Changes in beta-endorphin levels in response to aerobic and anaerobic exercise.

Authors:  L Schwarz; W Kindermann
Journal:  Sports Med       Date:  1992-01       Impact factor: 11.136

6.  Beta-endorphin, adrenocorticotropic hormone, cortisol and catecholamines during aerobic and anaerobic exercise.

Authors:  L Schwarz; W Kindermann
Journal:  Eur J Appl Physiol Occup Physiol       Date:  1990

7.  Changes in free cytosolic calcium and accumulation of inositol phosphates in isolated hepatocytes by [Leu]enkephalin.

Authors:  R P Leach; S B Shears; C J Kirk; M A Titheradge
Journal:  Biochem J       Date:  1986-09-01       Impact factor: 3.857

8.  [Leu]enkephalin stimulates carbohydrate metabolism in isolated hepatocytes and kidney tubule fragments by interaction with angiotensin II receptors.

Authors:  S K Hothi; D P Randall; M A Titheradge
Journal:  Biochem J       Date:  1989-02-01       Impact factor: 3.857

9.  L-Cysteine ethyl ester reverses the deleterious effects of morphine on, arterial blood-gas chemistry in tracheotomized rats.

Authors:  James Mendoza; Rachael Passafaro; Santhosh Baby; Alex P Young; James N Bates; Benjamin Gaston; Stephen J Lewis
Journal:  Respir Physiol Neurobiol       Date:  2013-07-23       Impact factor: 1.931

10.  The stimulation of glycogenolysis in isolated hepatocytes by opioid peptides.

Authors:  R P Leach; E H Allan; M A Titheradge
Journal:  Biochem J       Date:  1985-04-01       Impact factor: 3.857
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