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Literature DB >> 6656993

Utilization of tyrosine and tryptophan for protein synthesis by undernourished developing rat brain.

Abstract

Incorporation of tracer doses of radiolabeled tryptophan and tyrosine into brain proteins was investigated in rats malnourished during gestation and lactation. Age and time dependent increases in the radioactivity was observed in the whole homogenate and in the TCA insoluble fraction. Protein malnourished rats showed increased incorporation of tryptophan and tyrosine. However the diet restricted (Pair-fed) animals showed increased incorporation of tyrosine only. The increased incorporation may probably be due to changes in the pool size of the amino acids and effective recycling of the amino acids. The enhanced utilization in protein synthesis may also probably offer a mechanism for conservation of these amino acids.

Entities: Chemical Disease Species

Mesh：

Substances：
Tyrosine
Tryptophan

Year: 1983 PMID： 6656993 DOI： 10.1007/BF00965002

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

30 in total

1. OXIDATION OF L-AMINO ACIDS AND INCORPORATION INTO PROTEIN IN HOMOGENATES OF BRAIN AT TWO STAGES OF DEVELOPMENT.

Authors: B SCHEPARTZ
Journal: J Neurochem Date: 1963-12 Impact factor: 5.372

2. Effects of developmental protein malnutrition on tryptophan utilization in brain and peripheral tissues.

Authors: M Miller; J P Leahy; F McConville; P J Morgane; O Resnick
Journal: Brain Res Bull Date: 1977 Sep-Oct Impact factor: 4.077

3. Regulatory significance of transfer RNA charging levels. I. Measurements of charging levels in livers of chow-fed rats, fasting rats, and rats fed balanced or imbalanced mixtures of amino acids.

Authors: R E Allen; P L Raines; D M Regen
Journal: Biochim Biophys Acta Date: 1969-10-22

Utilization of tyrosine and tryptophan for protein synthesis by undernourished developing rat brain.

1. OXIDATION OF L-AMINO ACIDS AND INCORPORATION INTO PROTEIN IN HOMOGENATES OF BRAIN AT TWO STAGES OF DEVELOPMENT.

2. Effects of developmental protein malnutrition on tryptophan utilization in brain and peripheral tissues.

3. Regulatory significance of transfer RNA charging levels. I. Measurements of charging levels in livers of chow-fed rats, fasting rats, and rats fed balanced or imbalanced mixtures of amino acids.

4. Neonatal malnutrition: neurochemical, hormonal and behavioral manifestations.

5. Precursor and age-dependent differences in in vivo rates of protein synthesis in the cerebral cortex.

6. Tryptophan availability: relation to elevated brain serotonin in developmentally protein-malnourished rats.

7. Alterations in cerebral protein metabolism in the progeny of protein-calorie-deficient rats.

8. Myelin synthesis during postnatal nutritional deprivation and subsequent rehabilitation.

9. Protein degradation rates in regions of the central nervous system in vivo during development.

10. Metabolism of amino acids in protein-calorie-deficient rats.

1. Serotonin synthesis, release and reuptake in terminals: a mathematical model.

2. Cane molasses as a source of precursors in the bioproduction of tryptophan by Bacillus subtilis.