A comparison between atenolol and metoprolol in respect of central nervous system side effects.

A double-blind crossover study was performed to compare the incidence of central nervous system (CNS) side effects with atenolol and metoprolol. Eleven women and 6 men who had previously developed such side effects on lipophilic beta-blockers were identified by means of a preliminary questionnaire. A 30-item psychiatric questionnaire was then used to detect changes in psychological status and possible CNS side effects. Discontinuation of the original lipophilic beta-blocker produced a significant improvement in quality of sleep, dreams, concentration, memory, energy and anxiety. Introduction of atenolol did not result in any significant CNS effects. With metoprolol, however, some effects occurred but not to the extent experienced prior to study on other more lipophilic beta-blockers. Blood pressure control was identical with both drugs.

RCT Entities:   Population Interventions Outcomes