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Literature DB >> 6646409

A quantitative determination of anticonvulsant-induced bone demineralization by an improved X-ray densitometry technique.

K Wolschendorf, K Vanselow, W D Möller, H Schulz.

Abstract

Quantitative studies of the influence of anticonvulsant drugs on bone mineral content of 88 epileptics were performed by a microcomputer-aided densitometer system. The results showed that the mineral content decreases significantly with the duration of the therapy. This decrease was found to be approximately 1.2% per year for a Diphenylhydantoin (DPH) monotherapy and 1.8% per year and 2.0% per year for a DPH plus Phenobarbital and DPH plus Carbamazepin combination therapy.

Entities: Chemical Disease

Mesh：

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Year: 1983 PMID： 6646409 DOI： 10.1007/BF00439210

Source DB: PubMed Journal: Neuroradiology ISSN： 0028-3940 Impact factor: 2.804

12 in total

1. Interaction of diphenylhydantoin (phenytoin) and phenobarbital with hormonal mediation of fetal rat bone resorption in vitro.

Authors: T J Hahn; C R Scharp; C A Richardson; L R Halstead; A J Kahn; S L Teitelbaum
Journal: J Clin Invest Date: 1978-08 Impact factor: 14.808

A quantitative determination of anticonvulsant-induced bone demineralization by an improved X-ray densitometry technique.

1. Interaction of diphenylhydantoin (phenytoin) and phenobarbital with hormonal mediation of fetal rat bone resorption in vitro.

2. Evidence of osteomalacia in an outpatient group of adult epileptics.

3. [Osteopathy through anticonvulsants: pathogenesis, clinic and therapy (author's transl)].

4. [Drug interactions in antiepileptic combination therapy].

Review 5. Current methods of in-vivo measurement of osteoporosis.

6. [Osteopathies in antiepileptic long-term therapy (preliminary report)].

7. Radiologic bone changes and hypocalcemia with anticonvulsant therapy in epilepsy.

8. [Critical reflections on the radiologic determination of bone mineral content].

9. Osteomalacia with long-term anticonvulsant therapy in epilepsy.

10. Phenobarbital-induced alterations in vitamin D metabolism.

1. Antiepileptic drugs and bone metabolism.