Literature DB >> 6644570

Mechanisms of potassium chloride release from compressed, hydrophilic, polymeric matrices: effect of entrapped air.

R W Korsmeyer, R Gurny, E Doelker, P Buri, N A Peppas.   

Abstract

The release of potassium chloride from hydroxypropyl methylcellulose matrices was investigated for tablets prepared with several different compression forces. It was determined that the release kinetics for these systems deviates significantly from the classical t1/2 dependence. This behavior was attributed to air entrapped in the matrix during preparation. Removal of the air prior to release restored the traditional t1/2 behavior.

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Year:  1983        PMID： 6644570     DOI： 10.1002/jps.2600721021

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  87 in total

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5.  Influence of the Component Excipients on the Quality and Functionality of a Transdermal Film Formulation.

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6.  Self-assembled polyelectrolyte complexes films as efficient compression coating layers for controlled-releasing tablets.

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8.  Effect of pH on sublingual absorption of oxycodone hydrochloride.

Authors:  Abeer M Al-Ghananeem; Ahmad H Malkawi; Peter A Crooks
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