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Literature DB >> 6644242

Detection of the complement fragment C5a in inflammatory exudates from the rabbit peritoneal cavity using radioimmunoassay.

Abstract

We describe a radioimmunoassay for rabbit C5a and its use to obtain evidence of extravascular C5a generation in two inflammatory reactions in the peritoneal cavity. These observations, together with the potent activity of C5a in inducing increased microvascular permeability involving circulating PMN leukocytes, strengthen the case for considering C5a an important inflammatory mediator. These findings offer an explanation for the many different experimental inflammatory reactions where oedema formation can be suppressed either by systemic depletion of complement or by depletion of circulating PMN leukocytes.

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Year: 1983 PMID： 6644242 PMCID： PMC2187170 DOI： 10.1084/jem.158.6.2177

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

8 in total

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Journal: Nature Date: 1981-02-19 Impact factor: 49.962

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Authors: J C Fantone; S L Kunkel; P A Ward
Journal: Annu Rev Physiol Date: 1982 Impact factor: 19.318

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Authors: T J Williams; M J Peck
Journal: Nature Date: 1977-12-08 Impact factor: 49.962

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Authors: H N Fernandez; T E Hugli
Journal: J Biol Chem Date: 1978-10-10 Impact factor: 5.157

8. Mediation of increased vascular permeability after complement activation. Histamine-independent action of rabbit C5a.

Authors: T J Williams; P J Jose
Journal: J Exp Med Date: 1981-01-01 Impact factor: 14.307

8 in total

25 in total

1. The chemoattractant des-Arg74-C5a regulates the expression of its own receptor on a monocyte-like cell line.

Authors: M D Barker; P J Jose; T J Williams; D R Burton
Journal: Biochem J Date: 1986-06-01 Impact factor: 3.857

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Authors: F Tanaka; A M Dannenberg; K Higuchi; M Nakamura; P J Pula; T E Hugli; R G Discipio; D L Kreutzer
Journal: Inflammation Date: 1997-04 Impact factor: 4.092

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Journal: Gut Date: 1989-07 Impact factor: 23.059

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Authors: M Rampart; P J Jose; T J Williams
Journal: Agents Actions Date: 1985-03

5. Role of platelet-activating factor (PAF) in platelet accumulation in rabbit skin: effect of the novel long-acting PAF antagonist, UK-74,505.

Authors: F Pons; A G Rossi; K E Norman; T J Williams; S Nourshargh
Journal: Br J Pharmacol Date: 1993-05 Impact factor: 8.739

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Journal: Am J Pathol Date: 1986-07 Impact factor: 4.307

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Journal: Br J Pharmacol Date: 1991-06 Impact factor: 8.739