Literature DB >> 6644

Changes in the particle size distribution during tableting of sulphathiazole powder.

J R Carless, A Sheak.   

Abstract

Five size fractions of sulphathiazole powder (volume surface mean diameter 155, 133, 86, 50 and 41 mum) were compressed into 12 mm diameter tablets on an instrumented single punch tablet machine. The size analysis of the tablet material after compression showed an attrition of the coarser fraction and an agglomeration of the finer fraction. It is postulated that there is a critical particle size where the effects of crushing and bonding cancel each other. The changes in particle size are discussed in relation to some of the compressive characteristics of the powder.

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Year:  1976        PMID： 6644     DOI： 10.1111/j.2042-7158.1976.tb04016.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  2 in total

1.  Studies on tableting properties of lactose. Part III. The consolidation behaviour of sieve fractions of crystalline alpha-lactose monohydrate.

Authors:  A H De Boer; H Vromans; C F Lerk; G K Bolhuis; K D Kussendrager; H Bosch
Journal:  Pharm Weekbl Sci       Date:  1986-04-25

2.  Studies on tableting properties of lactose. Part 2. Consolidation and compaction of different types of crystalline lactose.

Authors:  H Vromans; A H De Boer; G K Bolhuis; C F Lerk; K D Kussendrager; H Bosch
Journal:  Pharm Weekbl Sci       Date:  1985-10-25
  2 in total

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