| Literature DB >> 6641911 |
Abstract
Jaundiced serum from common bile duct ligated rats, added to cultured heart cells, decreased the beating rate, caused an early cessation of beating and production of higher levels of lactate in the media. Deoxycholate and cholate are the main bile acids in jaundiced serum; deoxycholate caused similar effects, which suggests that it is the toxic substance responsible for heart function alterations seen in patients with severe jaundice.Entities:
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Year: 1983 PMID: 6641911 DOI: 10.1007/BF01990384
Source DB: PubMed Journal: Experientia ISSN: 0014-4754