Literature DB >> 639363

Cholic acid and the heart: in vitro studies of the effect on heart rate and myocardial contractility in the rat.

P Joubert.   

Abstract

1. Cholic acid has a dose-dependent negative chronotropic effect on isolated atria of Wistar rats. 2. The positive inotropic effect of cholic acid is the result of a negative chronotropic effect and can be eliminated by electrical pacing. 3. Cholic acid does not appear to exert its negative chronotropic effect through cholinoceptors and alterations in bath concentrations of calcium and potassium does not influence this effect significantly. 4. Cholic acid is a functional antagonist of isoprenaline. 5. It is suggested that cholic acid exerts its negative chronotropic effect by forming a monolayer on the surface of the cell membrane, thereby mechanically interfering with membrane function.

Entities:  

Mesh：

Substances：

Year:  1978        PMID： 639363     DOI： 10.1111/j.1440-1681.1978.tb00646.x

Source DB:  PubMed          Journal:  Clin Exp Pharmacol Physiol        ISSN： 0305-1870            Impact factor:   2.557


  12 in total

1.  QT interval prolongation in end-stage liver disease cannot be explained by nonhepatic factors.

Authors:  Divyang Patel; Prabhpreet Singh; William Katz; Christopher Hughes; Kapil Chopra; Jan Němec
Journal:  Ann Noninvasive Electrocardiol       Date:  2014-04-24       Impact factor: 1.468

Review 2.  Bile acids regulate cardiovascular function.

Authors:  Sandeep Khurana; Jean-Pierre Raufman; Thomas L Pallone
Journal:  Clin Transl Sci       Date:  2011-06       Impact factor: 4.689

3.  Effect of bile acid on electrophysiological properties of rabbit sino-atrial node in vitro.

Authors:  H Kotake; T Itoh; M Watanabe; I Hisatome; J Hasegawa; H Mashiba
Journal:  Br J Pharmacol       Date:  1989-10       Impact factor: 8.739

4.  Cardiomyopathy reverses with recovery of liver injury, cholestasis and cholanemia in mouse model of biliary fibrosis.

Authors:  Moreshwar S Desai; Zeena Eblimit; Sundararajah Thevananther; Astrid Kosters; David D Moore; Daniel J Penny; Saul J Karpen
Journal:  Liver Int       Date:  2014-01-12       Impact factor: 5.828

5.  Cardiac structural and functional alterations in infants and children with biliary atresia, listed for liver transplantation.

Authors:  Moreshwar S Desai; Shabier Zainuer; Curtis Kennedy; Debra Kearney; John Goss; Saul J Karpen
Journal:  Gastroenterology       Date:  2011-07-14       Impact factor: 22.682

6.  Bile acid excess induces cardiomyopathy and metabolic dysfunctions in the heart.

Authors:  Moreshwar S Desai; Bhoomika Mathur; Zeena Eblimit; Hernan Vasquez; Heinrich Taegtmeyer; Saul J Karpen; Daniel J Penny; David D Moore; Sayeepriyadarshini Anakk
Journal:  Hepatology       Date:  2016-11-29       Impact factor: 17.425

7.  The effect of jaundiced sera and bile salts on cultured beating rat heart cells.

Authors:  E Bogin; O Better; I Harari
Journal:  Experientia       Date:  1983-11-15

8.  Bile acids induce arrhythmias: old metabolite, new tricks.

Authors:  Moreshwar S Desai; Daniel J Penny
Journal:  Heart       Date:  2013-08-22       Impact factor: 5.994

9.  Effects of bile acids on ventricular muscle contraction and electrophysiological properties: studies in rat papillary muscle and isolated ventricular myocytes.

Authors:  O Binah; I Rubinstein; A Bomzon; O S Better
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-02       Impact factor: 3.000

10.  Mechanism of bile salt vasoactivity: dependence on calcium channels in vascular smooth muscle.

Authors:  J M Pak; A S Adeagbo; C R Triggle; E A Shaffer; S S Lee
Journal:  Br J Pharmacol       Date:  1994-08       Impact factor: 8.739
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.