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Literature DB >> 6641701

Correlation between endogenous nucleosomal hyper(ADP-ribosyl)ation of histone H1 and the induction of chromatin relaxation.

R J Aubin, A Fréchette, G de Murcia, P Mandel, A Lord, G Grondin, G G Poirier.

Abstract

The effect of poly(ADP-ribose) synthesis on chromatin structure was investigated by velocity sedimentation and electron microscopy. We demonstrate that locally relaxed regions can be generated within polynucleosome chains by the activity of their intrinsic poly(ADP-ribose)polymerase. This relaxation phenomenon is also shown to be NAD dependent and to be correlated with the formation of hyper(ADP-ribosyl)ated forms of histone H1. Evidence is also presented which suggests that hyper(ADP-ribosyl)ated histone H1 is neither released from the relaxed chromatin, nor does it seem to participate in polynucleosomal aggregation.

Entities: Chemical

Mesh：

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Year: 1983 PMID： 6641701 PMCID： PMC555344 DOI： 10.1002/j.1460-2075.1983.tb01643.x

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

62 in total

1. Electron microscopic and biochemical evidence that chromatin structure is a repeating unit.

Authors: P Oudet; M Gross-Bellard; P Chambon
Journal: Cell Date: 1975-04 Impact factor: 41.582

2. Stimulation of nuclear poly (adenosine diphosphate-ribose) polymerase activity from HeLa cells by endonucleases.

Authors: E G Miller
Journal: Biochim Biophys Acta Date: 1975-06-16

3. Effect of deoxyribonuclease I on the number and length of chains of poly(ADP-ribose) synthesized, in vitro.

Authors: E G Miller
Journal: Biochem Biophys Res Commun Date: 1975-09-02 Impact factor: 3.575

4. Natural occurrence of poly(ADP-ribosyl) histones in rat liver.

Authors: K Ueda; A Omachi; M Kawaichi; O Hayaishi
Journal: Proc Natl Acad Sci U S A Date: 1975-01 Impact factor: 11.205

Review 5. Structure of chromatin.

Authors: R D Kornberg
Journal: Annu Rev Biochem Date: 1977 Impact factor: 23.643

6. Spheroid chromatin units (v bodies).

Authors: A L Olins; D E Olins
Journal: Science Date: 1974-01-25 Impact factor: 47.728

7. 1-methyl-1-nitrosourea and dialkylnitrosamine depression of nicotinamide adenine dinucleotide.

Authors: P S Schein
Journal: Cancer Res Date: 1969-06 Impact factor: 12.701

8. Magnetic resonance studies of deoxyribonucleoprotein.

Authors: E M Bradbury; B G Carpenter; H W Rattle
Journal: Nature Date: 1973-01-12 Impact factor: 49.962

Review 9. Chromosome structure.

Authors: H Ris; D F Kubai
Journal: Annu Rev Genet Date: 1970 Impact factor: 16.830

9. Enhancement of cisplatin (DDP) antitumor activity by 3-aminobenzamide in rat ovarian tumors sensitive and resistant to DDP in vivo.

Authors: G Chen; W J Zeller
Journal: Cancer Chemother Pharmacol Date: 1990 Impact factor: 3.333

10. Inhibition of calf thymus type II DNA topoisomerase by poly(ADP-ribosylation).

Authors: M K Darby; B Schmitt; J Jongstra-Bilen; H P Vosberg
Journal: EMBO J Date: 1985-08 Impact factor: 11.598

Correlation between endogenous nucleosomal hyper(ADP-ribosyl)ation of histone H1 and the induction of chromatin relaxation.

1. Electron microscopic and biochemical evidence that chromatin structure is a repeating unit.

2. Stimulation of nuclear poly (adenosine diphosphate-ribose) polymerase activity from HeLa cells by endonucleases.

3. Effect of deoxyribonuclease I on the number and length of chains of poly(ADP-ribose) synthesized, in vitro.

4. Natural occurrence of poly(ADP-ribosyl) histones in rat liver.

Review 5. Structure of chromatin.

6. Spheroid chromatin units (v bodies).

7. 1-methyl-1-nitrosourea and dialkylnitrosamine depression of nicotinamide adenine dinucleotide.

8. Magnetic resonance studies of deoxyribonucleoprotein.

Review 9. Chromosome structure.

10. The role of histones in the maintenance of chromatin structure.

1. A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage.

2. Re-evaluating PARP1 inhibitor in cancer.

3. Co-operative interactions of oligonucleosomal DNA with the H1e histone variant and its poly(ADP-ribosyl)ated isoform.

4. Accumulation of 10-kilobase DNA replication intermediates in cells treated with 3-aminobenzamide.

Review 5. Poly-ADP-ribose polymerase: machinery for nuclear processes.

6. Uncoupling of the transactivation and transrepression functions of PARP1 protein.

7. Poly(ADP-ribose) may signal changing metabolic conditions to the chromatin of mammalian cells.

8. Large-scale preparation and characterization of poly(ADP-ribose) and defined length polymers.

9. Enhancement of cisplatin (DDP) antitumor activity by 3-aminobenzamide in rat ovarian tumors sensitive and resistant to DDP in vivo.

10. Inhibition of calf thymus type II DNA topoisomerase by poly(ADP-ribosylation).