Literature DB >> 6639696

A new model of osteoarthritis in rabbits. III. Evaluation of anti-osteoarthritic effects of selected drugs administered intraarticularly.

M Butler, C Colombo, L Hickman, E O'Byrne, R Steele, B Steinetz, J Quintavalla, N Yokoyama.   

Abstract

A battery of steroidal and nonsteroidal antirheumatic drugs and protease inhibitors were tested by intraarticular injection for effects on osteoarthritis of the knees of rabbits subjected to partial lateral meniscectomy and section of the sesamoid and collateral fibular ligaments. Among the standard drugs, only the glucocorticoid, triamcinolone hexacetonide, and the protease inhibitor, tranexamic acid, exhibited significant anti-osteoarthritic activity. An experimental drug, GPA 2163, also offered some protection against joint degeneration. The nonsteroidal antiinflammatory drugs had no effect on the development of osteoarthritis in the model.

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Year:  1983        PMID： 6639696     DOI： 10.1002/art.1780261111

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN： 0004-3591


  13 in total

Review 1.  Intra-articular corticosteroid injections in osteoarthritis: do they work and if so, how?

Authors:  P Creamer
Journal:  Ann Rheum Dis       Date:  1997-11       Impact factor: 19.103

2.  In vitro effects of tiaprofenic acid, sodium salicylate and hydrocortisone on human osteoarthritic cartilage degradation and synovial collagenase synthesis.

Authors:  J P Pelletier; J Martel-Pelletier
Journal:  Drugs       Date:  1988       Impact factor: 9.546

3.  Plasminogen modulation of IL-1-stimulated degradation in bovine and human articular cartilage explants. The role of the endogenous inhibitors: PAI-1, alpha 2-antiplasmin, alpha 1-PI, alpha 2-macroglobulin and TIMP.

Authors:  J Oleksyszyn; A J Augustine
Journal:  Inflamm Res       Date:  1996-09       Impact factor: 4.575

Review 4.  A risk-benefit assessment of intra-articular corticosteroids in rheumatic disorders.

Authors:  J A Hunter; T H Blyth
Journal:  Drug Saf       Date:  1999-11       Impact factor: 5.606

Review 5.  Toxicity of tranexamic acid (TXA) to intra-articular tissue in orthopaedic surgery: a scoping review.

Authors:  Scott M Bolam; Arama O'Regan-Brown; A Paul Monk; David S Musson; Jillian Cornish; Jacob T Munro
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2020-08-29       Impact factor: 4.342

Review 6.  Pirprofen. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy.

Authors:  P A Todd; R Beresford
Journal:  Drugs       Date:  1986-12       Impact factor: 9.546

7.  Spontaneous osteo-arthritis of the knee-joint in C57BL mice receiving chronic oral treatment with NSAID's or prednisone.

Authors:  A Pataki; H P Graf; E Witzemann
Journal:  Agents Actions       Date:  1990-03

8.  Physiological levels of hydrocortisone maintain an optimal chondrocyte extracellular matrix metabolism.

Authors:  J Wang; D Elewaut; I Hoffman; E M Veys; G Verbruggen
Journal:  Ann Rheum Dis       Date:  2004-01       Impact factor: 19.103

9.  Protective effect of rimexolone on cartilage damage in arthritic mice: a comparative study with triamcinolone hexacetonide.

Authors:  L A Joosten; M M Helsen; W B van den Berg
Journal:  Agents Actions       Date:  1990-08

Review 10.  Osteoarthritis. A continuing challenge.

Authors:  K E Sack
Journal:  West J Med       Date:  1995-12
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