Minimal inhibitory concentrations of lucknomycin, a new polyenic derivative, for Candida and Aspergillus spp.

The minimal inhibitory concentrations (MICs) of lucknomycin, a new polyenic derivative, were determined for 101 clinical isolates of Candida, 38 clinical or environmental strains of Aspergillus fumigatus, and 30 isolates of A. niger. The most susceptible species were Candida albicans and Candida tropicalis (mean MIC, 0.4 micrograms/ml). Aspergillus spp. were less susceptible, with mean MICs of 0.60 micrograms/ml for Aspergillus niger and 9.2 micrograms/ml for Aspergillus fumigatus.