| Literature DB >> 1097545 |
J Z Montgomerie, J E Edwards, L B Guze.
Abstract
The in vitro activity of amphotericin B and 5-fluorocytosine against 40 isolates of different species of Candida was studied. Synergism was seen in 35 of 40 organisms studied (88%) with achievable serum concentrations of the antibiotics. Synergism was striking in many strains that were resistant to 5-fluorocytosine. When the minimal inhibitory concentration of 5-fluorocytosine was greater than 400 mug/ml, synergism was seen in 18 of 20 isolates of Candida (90%).Entities:
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Year: 1975 PMID： 1097545 DOI： 10.1093/infdis/132.1.82
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226