Literature DB >> 6619099

Local anesthetics block transient expression of inducible functions for transformation in Streptococcus sanguis.

J L Raina.   

Abstract

Procaine and tetracaine reversibly inhibit transformation by preventing the transient expression of competence-specific, inducible functions, which are usually triggered in response to cellular stimulation with competence protein. Affinity studies with 14C-labeled procaine showed that the anesthetic bound to cell surface macromolecules specifically in the initiation phases of competence-specific events and blocked transfer of information imparted by cellular membrane receptor(s) upon interaction with competence protein.

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Year:  1983        PMID： 6619099      PMCID： PMC215107          DOI： 10.1128/jb.156.1.450-454.1983

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  17 in total

1.  Fate of heterospecific transforming DNA bound to Streptococcus sanguis.

Authors:  J L Raina; E Metzer; A W Ravin
Journal:  J Bacteriol       Date:  1978-03       Impact factor: 3.490

Review 2.  The membrane actions of anesthetics and tranquilizers.

Authors:  P Seeman
Journal:  Pharmacol Rev       Date:  1972-12       Impact factor: 25.468

3.  Conversion of biomembrane-produced energy into electric form. I. Submitochondrial particles.

Authors:  L L Grinius; A A Jasaitis; Y P Kadziauskas; E A Liberman; V P Skulachev; V P Topali; L M Tsofina; M A Vladimirova
Journal:  Biochim Biophys Acta       Date:  1970-08-04

4.  Competence for genetic transformation in pneumococcus depends on synthesis of a small set of proteins.

Authors:  D A Morrison; M F Baker
Journal:  Nature       Date:  1979-11-08       Impact factor: 49.962

5.  Presynaptic donor DNA-protein complexes in transformation of Streptococcus sanguis: identification of the protein component.

Authors:  J L Raina; A W Ravin
Journal:  Biochem Biophys Res Commun       Date:  1980-03-13       Impact factor: 3.575

6.  Local anesthetics block induction of the Pseudomonas alk regulon.

Authors:  S A Benson
Journal:  J Bacteriol       Date:  1979-12       Impact factor: 3.490

7.  Neuroactive drugs inhibit trypsin and outer membrane protein processing in Escherichia coli K-12.

Authors:  R C Gayda; G W Henderson; A Markovitz
Journal:  Proc Natl Acad Sci U S A       Date:  1979-05       Impact factor: 11.205

8.  Procaine, a local anesthetic interacting with the cell membrane, inhibits the processing of precursor forms of periplasmic proteins in Escherichia coli.

Authors:  C Lazdunski; D Baty; J M Pagès
Journal:  Eur J Biochem       Date:  1979-05-02

9.  Fate of homospecific transforming DNA bound to Streptococcus sanguis.

Authors:  J L Raina; A W Ravin
Journal:  J Bacteriol       Date:  1978-03       Impact factor: 3.490

10.  In vivo effects of local anesthetics on the production of major outer membrane proteins by Escherichia coli.

Authors:  A P Pugsley; D J Conrard; C A Schnaitman; T I Gregg
Journal:  Biochim Biophys Acta       Date:  1980-06-20
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