Literature DB >> 6618806

Evidence for rod outer segment lipid peroxidation following constant illumination of the rat retina.

R D Wiegand, N M Giusto, L M Rapp, R E Anderson.   

Abstract

Constant illumination for three days (100-125 foot-candles) caused degeneration of photoreceptor cells in the albino rat retina and was accompanied by a reduction in the levels of docosahexaenoic acid (22:6 omega 3), the major polyunsaturated fatty acid in rod outer segments (ROS). An increase in the level of lipid conjugated dienes, a measure of lipid hydroperoxides, also was observed in ROS after 24-72 hours of constant illumination. These data support the suggestion that peroxidation of long-chain polyunsaturated fatty acids in ROS may be a factor in light-induced retinal degeneration.

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Year:  1983        PMID： 6618806

Source DB:  PubMed          Journal:  Invest Ophthalmol Vis Sci        ISSN： 0146-0404            Impact factor:   4.799


  37 in total

1.  Viral-mediated FGF-2 treatment of the constant light damage model of photoreceptor degeneration.

Authors:  Dana Lau; John Flannery
Journal:  Doc Ophthalmol       Date:  2003-01       Impact factor: 2.379

2.  Retinal sensitivity loss in third-generation n-3 PUFA-deficient rats.

Authors:  Harrison S Weisinger; James A Armitage; Brett G Jeffrey; Drake C Mitchell; Toru Moriguchi; Andrew J Sinclair; Richard S Weisinger; Norman Salem
Journal:  Lipids       Date:  2002-08       Impact factor: 1.880

Review 3.  DNA repair in photoreceptor survival.

Authors:  M Soledad Cortina; William C Gordon; Walter J Lukiw; Nicolas G Bazan
Journal:  Mol Neurobiol       Date:  2003-10       Impact factor: 5.590

4.  Redox proteomic identification of visual arrestin dimerization in photoreceptor degeneration after photic injury.

Authors:  Christopher J Lieven; Jonathan D Ribich; Megan E Crowe; Leonard A Levin
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-06-26       Impact factor: 4.799

5.  Expression patterns of iron regulatory proteins after intense light exposure in a cone-dominated retina.

Authors:  Meenakshi Maurya; Tapas C Nag; Pankaj Kumar; Tara Sankar Roy
Journal:  Mol Cell Biochem       Date:  2021-05-13       Impact factor: 3.396

6.  Blue light-triggered photochemistry and cytotoxicity of retinal.

Authors:  Kasun Ratnayake; John L Payton; Mitchell E Meger; Nipunika H Godage; Emanuela Gionfriddo; Ajith Karunarathne
Journal:  Cell Signal       Date:  2020-01-23       Impact factor: 4.315

Review 7.  Retinal light damage: mechanisms and protection.

Authors:  Daniel T Organisciak; Dana K Vaughan
Journal:  Prog Retin Eye Res       Date:  2009-12-03       Impact factor: 21.198

8.  Induced pluripotent stem cells without c-Myc ameliorate retinal oxidative damage via paracrine effects and reduced oxidative stress in rats.

Authors:  I-Mo Fang; Chang-Hao Yang; Shih-Hwa Chiou; Chung-May Yang
Journal:  J Ocul Pharmacol Ther       Date:  2014-08-14       Impact factor: 2.671

9.  Light-evoked arachidonic acid release in the retina: illuminance/duration dependence and the effects of quinacrine, mellitin and lithium. Light-evoked arachidonic acid release.

Authors:  H Jung; C Remé
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1994-03       Impact factor: 3.117

10.  Gene and noncoding RNA regulation underlying photoreceptor protection: microarray study of dietary antioxidant saffron and photobiomodulation in rat retina.

Authors:  Riccardo Natoli; Yuan Zhu; Krisztina Valter; Silvia Bisti; Janis Eells; Jonathan Stone
Journal:  Mol Vis       Date:  2010-09-03       Impact factor: 2.367
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