Literature DB >> 12675490

Viral-mediated FGF-2 treatment of the constant light damage model of photoreceptor degeneration.

Dana Lau1, John Flannery.   

Abstract

These experiments evaluate overexpression of basic fibroblast growth factor (FGF-2) as a treatment to decrease photoreceptor cell death in the constant light damage model of retinal degeneration. Increased FGF-2 expression was accomplished by gene transfer to the retina via injection into the subretinal space of a recombinant adeno-associated virus (rAAV), containing the FGF-2 gene. Rescue effects were assessed by morphometry and electroretinographic analysis.

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Year:  2003        PMID： 12675490     DOI： 10.1023/a:1022481306146

Source DB:  PubMed          Journal:  Doc Ophthalmol        ISSN： 0012-4486            Impact factor:   2.379


  20 in total

1.  Recombinant AAV-mediated delivery of a tet-inducible reporter gene to the rat retina.

Authors:  L H McGee Sanftner; K G Rendahl; D Quiroz; M Coyne; M Ladner; W C Manning; J G Flannery
Journal:  Mol Ther       Date:  2001-05       Impact factor: 11.454

2.  Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus.

Authors:  J G Flannery; S Zolotukhin; M I Vaquero; M M LaVail; N Muzyczka; W W Hauswirth
Journal:  Proc Natl Acad Sci U S A       Date:  1997-06-24       Impact factor: 11.205

3.  Support for the equivalent light hypothesis for RP.

Authors:  J Lisman; G Fain
Journal:  Nat Med       Date:  1995-12       Impact factor: 53.440

4.  Glial cell line derived neurotrophic factor delays photoreceptor degeneration in a transgenic rat model of retinitis pigmentosa.

Authors:  L H McGee Sanftner; H Abel; W W Hauswirth; J G Flannery
Journal:  Mol Ther       Date:  2001-12       Impact factor: 11.454

5.  Retinal damage by light in rats.

Authors:  W K Noell; V S Walker; B S Kang; S Berman
Journal:  Invest Ophthalmol       Date:  1966-10

6.  Functional protection of photoreceptors from light-induced damage by dimethylthiourea and Ginkgo biloba extract.

Authors:  I Ranchon; J M Gorrand; J Cluzel; M T Droy-Lefaix; M Doly
Journal:  Invest Ophthalmol Vis Sci       Date:  1999-05       Impact factor: 4.799

7.  Preconditioning with bright light evokes a protective response against light damage in the rat retina.

Authors:  C Liu; M Peng; A M Laties; R Wen
Journal:  J Neurosci       Date:  1998-02-15       Impact factor: 6.167

8.  Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats.

Authors:  R J Mandel; S K Spratt; R O Snyder; S E Leff
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-09       Impact factor: 11.205

9.  Evidence for rod outer segment lipid peroxidation following constant illumination of the rat retina.

Authors:  R D Wiegand; N M Giusto; L M Rapp; R E Anderson
Journal:  Invest Ophthalmol Vis Sci       Date:  1983-10       Impact factor: 4.799

10.  Protection of the rat retina from ischemic injury by brain-derived neurotrophic factor, ciliary neurotrophic factor, and basic fibroblast growth factor.

Authors:  K Unoki; M M LaVail
Journal:  Invest Ophthalmol Vis Sci       Date:  1994-03       Impact factor: 4.799
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  3 in total

Review 1.  [Survival factors in the treatment of hereditary retinal degeneration].

Authors:  R Frigg; A Wenzel; C Grimm; C E Remé
Journal:  Ophthalmologe       Date:  2005-08       Impact factor: 1.059

Review 2.  The effect of oxygen and light on the structure and function of the neonatal rat retina.

Authors:  A L Dorfman; S Joly; P Hardy; S Chemtob; P Lachapelle
Journal:  Doc Ophthalmol       Date:  2008-05-16       Impact factor: 2.379

3.  Adult human periodontal ligament-derived stem cells delay retinal degeneration and maintain retinal function in RCS rats.

Authors:  Li Huang; Zongyi Li; Haibin Tian; Weiguo Wang; Dawei Cui; Zhe Zhou; Xiao Chen; Herman S Cheung; Guo-Tong Xu; Yu Chen
Journal:  Stem Cell Res Ther       Date:  2017-12-22       Impact factor: 6.832
  3 in total

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